Evidence map›Paper›PMID 28587901›Full record

ReviewNeuroscience letters2018

Flexible weighting of diverse inputs makes hippocampal function malleable.

Mariam Aly, Nicholas B Turk-Browne

Abstract readReview
In one paragraph

Review in Neuroscience letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Switching between External and Internal Attention in Hippocampal Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  8. Review
  9. Article
  10. Article
  11. Challenges in Understanding the Role of Reactivation in Modifying Hippocampal Representations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Hippocampal Shape Maturation in Childhood and Adolescence.Cerebral cortex (New York, N.Y. : 1991) · 2019
    Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mariam AlyPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, 08544, United States; Department of Psychology, Columbia University, New York, NY, 10027, United States. Electronic address: ma3631@columbia.edu.
Nicholas B Turk-BrownePrinceton Neuroscience Institute, Princeton University, Princeton, NJ, 08544, United States; Department of Psychology, Princeton University, Princeton, NJ, 08544, United States; Department of Psychology, Yale University, New Haven, CT, 06520, United States.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Neural and Behavioral Interactions Between Attention, Perception, and LearningR01EY021755 · NEI · PRINCETON UNIVERSITY · PI TURK-BROWNE, NICHOLAS BENJAMIN · 2011 to 2015
$1.8M
NCATS NIH HHS UL1 TR001863NEI NIH HHS R01 EY021755
6 · The paper itself

Abstract

Classic theories of hippocampal function have emphasized its role as a dedicated memory system, but recent research has shown that it contributes broadly to many aspects of cognition, including attention and perception. We propose that the reason the hippocampus plays such a broad role in cognition is that its function is particularly malleable. We argue that this malleability arises because the hippocampus receives diverse anatomical inputs and these inputs are flexibly weighted based on behavioral goals. We discuss examples of how hippocampal representations can be flexibly weighted, focusing on hippocampal modulation by attention. Finally, we suggest some general neural mechanisms and core hippocampal computations that may enable the hippocampus to support diverse cognitive functions, including attention, perception, and memory. Together, this work suggests that great progress can and has been made in understanding the hippocampus by considering how the domain-general computations it performs allow it to dynamically contribute to many different behaviors.

Indexed as

AttentionHippocampusHumansMemoryPerceptionEpisodic memoryMatch/mismatch detectionPattern completionPattern separationRelational representations

Identifiers

PMID28587901
PMCPMC5712489

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.