ArticlePsychological medicine2017
Neurocognitive subtypes in patients with bipolar disorder and their unaffected siblings.
Article in Psychological medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- A Systematic Review of Cognition-Brain Morphology Relationships on the Schizophrenia-Bipolar Disorder Spectrum.Schizophrenia bulletin · 2021Pooled it
- A Systematic Review of Studies Reporting Data-Driven Cognitive Subtypes across the Psychosis Spectrum.Neuropsychology review · 2020Pooled it
- Characterizing high cognitive performance in persons with mood disorders and their unaffected relatives: associations with emotional cognition, functioning, and clinical outcomes.International journal of bipolar disorders · 2026Article
- Virtual reality-based cognitive screening in psychiatry: Investigating optimal cut-offs for cognitive impairment in bipolar disorder.Neuroscience applied · 2026Article
- Irony comprehension in first-degree relatives of patients with bipolar affective disorder - a preliminary fMRI study.Frontiers in psychiatry · 2025Article
- Transdiagnostic subgroups of cognitive impairment in early affective and psychotic illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Biomarkers for neurodegeneration impact cognitive function: a longitudinal 1-year case-control study of patients with bipolar disorder and healthy control individuals.International journal of bipolar disorders · 2024Article
- Efficacy of Functional Remediation on Cognitive and Psychosocial Functioning in Patients with Bipolar Disorder: Study Protocol for a Randomized Controlled Study.Brain sciences · 2023Article
- Neurocognitive Subgroups in Children at Familial High-risk of Schizophrenia or Bipolar disorder: Subgroup Membership Stability or Change From Age 7 to 11-The Danish High Risk and Resilience Study.Schizophrenia bulletin · 2023Article
- First-Episode Psychosis Patients Who Deteriorated in the Premorbid Period Do Not Have Higher Polygenic Risk Scores Than Others: A Cluster Analysis of EU-GEI Data.Schizophrenia bulletin · 2023Article
- Functional Alterations in Patients with Bipolar Disorder and Their Unaffected First-Degree Relatives: Insight from Genetic, Epidemiological, and Neuroimaging Data.Neuropsychiatric disease and treatment · 2023Review
- Facial processing in bipolar disorder is mediated by clinical and biological aspects.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2022Article
- Interactive effects of polygenic risk and cognitive subtype on brain morphology in schizophrenia spectrum and bipolar disorders.European archives of psychiatry and clinical neuroscience · 2022Article
- Heterogeneity of social cognitive and language functions in children at familial high-risk of severe mental illness; The Danish High Risk and Resilience Study VIA 7.European child & adolescent psychiatry · 2022Article
- Cognitive heterogeneity is a key predictor of differential functional outcome in patients with bipolar disorder.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2021Article
- Mismatch negativity amplitude in first-degree relatives of individuals with psychotic disorders: Links with cognition and schizotypy.Schizophrenia research · 2021Article
- Neuropsychology of Bipolar Disorder.Current topics in behavioral neurosciences · 2021Article
- The Greater Houston Area Bipolar Registry-Clinical and Neurobiological Trajectories of Children and Adolescents With Bipolar Disorders and High-Risk Unaffected Offspring.Frontiers in psychiatry · 2021Article
- Progression of the functional deficit in a group of patients with bipolar disorder: a cluster analysis based on longitudinal data.European archives of psychiatry and clinical neuroscience · 2020Article
- Role of cognitive reserve in cognitive variability in euthymic individuals with bipolar disorder: cross-sectional cluster analysis.BJPsych open · 2020Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundOur previous work revealed substantial heterogeneity in the cognitive profile of bipolar disorder (BD) due to the presence of three underlying cognitive subgroups characterized as: globally impaired, selectively impaired, or cognitively intact. In an effort to determine whether these subgroups are differentially related to genetic risk for the illness, we investigated whether cognitive deficits were more pronounced in unaffected siblings (UAS) of BD probands within identified clusters.
methodsCluster analysis was used to identify cognitive clusters in BD (N = 60). UAS (N = 49) were classified into groups according to their proband sibling's cluster assignment; comparisons were made across all clusters and healthy controls (HCs; N = 71).
resultsThree cognitive clusters in BD emerged: a globally impaired (36.7%), a selectively impaired (30%), and a cognitively intact cluster (33.3%). UAS showed a qualitatively similar pattern to their BD siblings; UAS of the globally impaired BD cluster showed verbal memory and general cognitive impairments relative to HCs. In contrast, UAS of the other two clusters did not differ from HCs.
conclusionsThis study corroborates findings from prior work regarding the presence of cognitive heterogeneity in BD. UAS of subjects in the globally impaired BD cluster presented with a qualitatively similar cognitive profile to their siblings and performed worse than all other BD clusters and UAS groups. This suggests that inherited risk factors may be contributing to cognitive deficits more notably in one subgroup of patients with BD, pointing toward differential causes of cognitive deficits in discrete subgroups of patients with the disorder.
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