ArticleCardiovascular diabetology2017
Impact of diabetes duration and degree of carotid artery stenosis on major adverse cardiovascular events: a single-center, retrospective, observational cohort study.
Article in Cardiovascular diabetology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Influencing factors of stroke in patients with type 2 diabetes: A systematic review and meta-analysis.PloS one · 2024Pooled it
- The Risk of Stroke and TIA in Nonstenotic Carotid Plaques: A Systematic Review and Meta-Analysis.AJNR. American journal of neuroradiology · 2020Pooled it
- Relation of insulin treatment for type 2 diabetes to the risk of major adverse cardiovascular events after acute coronary syndrome: an analysis of the BETonMACE randomized clinical trial.Cardiovascular diabetology · 2021Trial
- The predictive value of C-reactive protein-triglycerides-glucose index-waist-to-height ratio for stroke: a nationwide cohort study.Cardiovascular diabetology · 2026Article
- Association of Diabetes Mellitus with Carotid Artery Stenosis Undergoing Coronary Artery Bypass Graft in Bangladesh: A Prospective Cross-Sectional Study.International journal of general medicine · 2025Article
- Differential ischemic stroke risk linked to novel subtypes of type 2 diabetes: insights from a Mendelian randomization analysis.Endocrine · 2024Article
- The correlation between severe asymptomatic carotid artery stenosis and severe multi-organ dysfunction after off-pump coronary artery bypass grafting.Frontiers in cardiovascular medicine · 2024Article
- Youth-onset type 2 diabetes mellitus: an urgent challenge.Nature reviews. Nephrology · 2023Review
- Association between diabetes duration and 1-year prognosis of stroke: A national registry study.Brain and behavior · 2022Article
- Diabetes Mellitus and Clinical Outcomes in Carotid Artery Revascularization Using Second-Generation, MicroNet-Covered Stents: Analysis from the PARADIGM Study.Journal of diabetes research · 2022Article
- Predictive nomogram for coronary heart disease in patients with type 2 diabetes mellitus.Frontiers in cardiovascular medicine · 2022Article
- Expression of miRNAs Targeting ATP Binding Cassette Transporter 1 (ABCA1) among Patients with Significant Carotid Artery Stenosis.Biomedicines · 2021Article
- Association Between Age at Diagnosis of Type 2 Diabetes and Cardiovascular Diseases: A Nationwide, Population-Based, Cohort Study.Frontiers in endocrinology · 2021Article
- Prognostic value of left ventricular mechanical dyssynchrony indices in long-standing type II diabetes mellitus with normal perfusion and left ventricular systolic functions on SPECT-MPI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Diabetes and carotid artery disease: a narrative review.Annals of translational medicine · 2020Review
- Carotid plaque imaging profiling in subjects with risk factors (diabetes and hypertension).Cardiovascular diagnosis and therapy · 2020Review
- Comparison of outcomes between type 2 diabetic and non-diabetic incident hemodialysis patients with functioning arteriovenous fistulas.Medicine · 2019Article
- Cholesterol levels and development of cardiovascular disease in Koreans with type 2 diabetes mellitus and without pre-existing cardiovascular disease.Cardiovascular diabetology · 2019Article
- Carotid ultrasound investigation as a prognostic tool for patients with diabetes mellitus.Cardiovascular diabetology · 2019Article
- Diagnostic value of color Doppler sonography for spontaneous isolated superior mesenteric artery dissection.Experimental and therapeutic medicine · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to investigate the impact of diabetes duration and carotid artery stenosis (CAS) on the occurrence of major adverse cardiovascular events (MACE) in patients with type 2 diabetes mellitus (T2DM) without clinical cardiovascular disease.
methodsA total of 2006 patients with T2DM, without clinical cardiovascular disease, aged >50 years, and who underwent baseline carotid Doppler ultrasound screening with regular follow-ups at the outpatient clinic of our diabetes center, were stratified into four subgroups according to diabetes duration and CAS degree. The primary outcomes included the occurrence of MACE, defined as fatal or nonfatal stroke and myocardial infarction, and all-cause mortality.
resultsThe difference in the MACE incidence was significantly greater in patients with a longer diabetes duration (≥10 years) and significant CAS (50-69% luminal narrowing) (p < 0.001). Analysis of individual MACE components indicated a trend towards an increased incidence of stroke (p < 0.001), parallel to a longer diabetes duration and significant CAS. In contrast, the risk of myocardial infarction was significantly higher in patients with a diabetes duration <10 years and significant CAS (p = 0.039). Multivariate regression analysis showed that patients with both a longer diabetes duration and significant CAS demonstrated additive and very high risks of MACE (hazard ratio [HR], 2.07; 95% confidence interval [CI] 1.17-3.66; p = 0.012) and stroke (HR, 3.38; 95% CI 1.54-7.44; p = 0.002).
conclusionsThe risk of MACE is significantly greater in patients with T2DM, without clinical cardiovascular disease, who have both a longer diabetes duration and significant CAS, compared with those who have a shorter duration and/or nonsignificant CAS.
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