Evidence map›Paper›PMID 28587398›Full record

ArticleExperimental and therapeutic medicine2017

Diazoxide protects rat vascular endothelial cells against hypoxia and cold-induced damage.

Lian-Cheng Zhang, Zhao Huang, Pei-Bing Li, Hong-Jing Nie, Bing-Nan Deng, Rui-Feng Duan, Zhong-Hai Xiao, Hui Peng, Hong Feng, Wei Liu

Open access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Lian-Cheng ZhangDepartment of Environment and Pharmacy, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, P.R. China.
Zhao HuangTianjin Key Laboratory of Exercise Physiology and Sports Medicine, Tianjin University of Sport, Tianjin 300381, P.R. China.
Pei-Bing LiDepartment of Environment and Pharmacy, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, P.R. China.
Hong-Jing NieDepartment of Environment and Pharmacy, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, P.R. China.
Bing-Nan DengDepartment of Environment and Pharmacy, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, P.R. China.
Rui-Feng DuanDepartment of Environment and Pharmacy, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, P.R. China.
Zhong-Hai XiaoDepartment of Environment and Pharmacy, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, P.R. China.
Hui PengDepartment of Environment and Pharmacy, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, P.R. China.
Hong FengTianjin Key Laboratory of Exercise Physiology and Sports Medicine, Tianjin University of Sport, Tianjin 300381, P.R. China.
Wei LiuDepartment of Environment and Pharmacy, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, P.R. China.
Tianjin University of Sport · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aimed to examine the effects of hypoxia and cold on vascular endothelial cells (VECs), as well as the protective ability of novel VECs-protective drugs against these injuries. A rat model simulating exposure to hypoxia and cold at high altitude environments was established. Based on these animal experiments, rat aortic VECs were established as injury models and exposed to hypoxia and/or adrenaline (ADR)

Indexed as

adrenalinecolddamage effectsdiazoxidehypoxiarat aortic endothelial cells

Identifiers

PMID28587398
PMCPMC5450562
OpenAlexW2610690285

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.