Evidence map›Paper›PMID 28587352›Full record

ArticleExperimental and therapeutic medicine2017

Interleukin-1 receptor antagonist expression is inversely associated with outcomes of hepatitis B-related acute-on-chronic liver failure.

Jinglan Lai, Yuming Liu, Chen Pan, Chun Lin, Fang Sun, Zuxiong Huang, Yong Lin, Rui Zhou, Yuanbao Lin, Yuanping Zhou

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. [Progress in clinical research on potential therapeutic drugs for acute-on-chronic liver failure].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jinglan LaiDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Yuming LiuDepartment of Infectious Disease, Infectious Disease Hospital of Fuzhou, Meng Chao Hepatobiliary Hospital, Fujian Medical University, Fuzhou, Fujian 350025, P.R. China.
Chen PanDepartment of Infectious Disease, Infectious Disease Hospital of Fuzhou, Meng Chao Hepatobiliary Hospital, Fujian Medical University, Fuzhou, Fujian 350025, P.R. China.
Chun LinDepartment of Infectious Disease, Infectious Disease Hospital of Fuzhou, Meng Chao Hepatobiliary Hospital, Fujian Medical University, Fuzhou, Fujian 350025, P.R. China.
Fang SunDepartment of Infectious Disease, Infectious Disease Hospital of Fuzhou, Meng Chao Hepatobiliary Hospital, Fujian Medical University, Fuzhou, Fujian 350025, P.R. China.
Zuxiong HuangDepartment of Infectious Disease, Infectious Disease Hospital of Fuzhou, Meng Chao Hepatobiliary Hospital, Fujian Medical University, Fuzhou, Fujian 350025, P.R. China.
Yong LinDepartment of Infectious Disease, Infectious Disease Hospital of Fuzhou, Meng Chao Hepatobiliary Hospital, Fujian Medical University, Fuzhou, Fujian 350025, P.R. China.
Rui ZhouDepartment of Infectious Disease, Infectious Disease Hospital of Fuzhou, Meng Chao Hepatobiliary Hospital, Fujian Medical University, Fuzhou, Fujian 350025, P.R. China.
Yuanbao LinDepartment of Infectious Disease, Infectious Disease Hospital of Fuzhou, Meng Chao Hepatobiliary Hospital, Fujian Medical University, Fuzhou, Fujian 350025, P.R. China.
Yuanping ZhouDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Mengchao Hepatobiliary Hospital · CNFujian Medical University · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin-1 receptor antagonist (IL-1ra) is a naturally occurring anti-inflammatory antagonist of the proinflammatory cytokine IL-1, a critical factor in many inflammatory diseases. The aim of the present study was to investigate the role of IL-1ra in hepatitis B-related acute-on-chronic liver failure (HB-ACLF). Serum cytokine concentrations were measured using a Q-Plex array in 31 patients with HB-ACLF, 28 patients with acute hepatitis B (AHB), 31 patients with chronic hepatitis B (CHB) and 15 healthy control patients (HCs). Additionally, peripheral blood mononuclear cells (PBMCs) from patients with HB-ACLF were incubated with PBS or lipopolysaccharide and/or different concentrations of recombinant human IL-1ra (rhIL-1ra)

Indexed as

acute-on-chronic liver failurechronic hepatitis Binterleukin-1 antagonist receptorperipheral blood mononuclear cellQ-Plex array

Identifiers

PMID28587352
PMCPMC5450678
OpenAlexW2605730475

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.