Evidence map›Paper›PMID 28587181›Full record

ReviewNutrients2017

Chronic Inflammatory Diseases and Green Tea Polyphenols.

Helieh S Oz

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Helieh S OzDepartment of Physiology, Internal Medicine, College of Medicine, University of Kentucky Medical Center, Lexington, KY 40536-0298, USA. hoz2@email.uky.edu.
University of Kentucky · US

Funding

Green Tea Polyphenols: A Novel Approach to IBDR21AT001490 · NCCIH · UNIVERSITY OF KENTUCKY · PI OZ, HELIEH S · 2004 to 2005
$365k
NCCIH NIH HHS R21 AT001490
6 · The paper itself

Abstract

Chronic inflammatory diseases affect millions of people globally and the incidence rate is on the rise. While inflammation contributes to the tissue healing process, chronic inflammation can lead to life-long debilitation and loss of tissue function and organ failure. Chronic inflammatory diseases include hepatic, gastrointestinal and neurodegenerative complications which can lead to malignancy. Despite the millennial advancements in diagnostic and therapeutic modalities, there remains no effective cure for patients who suffer from inflammatory diseases. Therefore, patients seek alternatives and complementary agents as adjunct therapies to relieve symptoms and possibly to prevent consequences of inflammation. It is well known that green tea polyphenols (GrTPs) are potent antioxidants with important roles in regulating vital signaling pathways. These comprise transcription nuclear factor-kappa B mediated I kappa B kinase complex pathways, programmed cell death pathways like caspases and B-cell lymphoma-2 and intervention with the surge of inflammatory markers like cytokines and production ofcyclooxygenase-2. This paper concisely reviews relevant investigations regarding protective effects of GrTPs and some reported adverse effects, as well as possible applications for GrTPs in the treatment of chronic and inflammatory complications.

Indexed as

AnimalsAntioxidantsApoptosisCell Line, TumorChronic DiseaseCytokinesDisease Models, AnimalGastrointestinal DiseasesHumansInflammationInflammatory Bowel DiseasesLiver DiseasesNeurodegenerative DiseasesNF-kappa BPolyphenolsRandomized Controlled Trials as TopicAntioxidantsCytokinesNF-kappa BPolyphenolsTeachronic inflammatory diseases(−)-Epigallocatechin-3-gallate (EGCG)green tea polyphenols

Identifiers

PMID28587181
PMCPMC5490540
OpenAlexW2619388062

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.