Evidence map›Paper›PMID 28587118›Full record

ReviewInternational journal of molecular sciences2017

Nerve Growth Factor and Related Substances: A Brief History and an Introduction to the International NGF Meeting Series.

Ralph A Bradshaw, William Mobley, Robert A Rush

Open access · goldAbstract readConference ProceedingsEditorialReview
In one paragraph

Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Ralph A BradshawDepartment of Physiology and Biophysics, University of California, Irvine, CA 92697, USA. rablab@uci.edu.
William MobleyDepartment of Neuroscience, University of California, San Diego, La Jolla, CA 92093, USA. williammobley7@gmail.com.
Robert A RushDepartment of Human Physiology, Flinders University, Adelaide, SA 5001, Australia. robert.rush@flinders.edu.au.
Flinders University · AUUniversity of California, Irvine · USUniversity of California, San Diego · US

Funding

Genetic Basis of Failed Cognition in Young and Aged Mouse Models of Trisomy 21R01NS066072 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MOBLEY, WILLIAM C, YU, EUGENE · 2010 to 2014
$3.2M
NINDS NIH HHS R01 NS066072
6 · The paper itself

Abstract

Nerve growth factor (NGF) is a protein whose importance to research and its elucidation of fundamental mechanisms in cell and neurobiology far outstrips its basic physiological roles. It was the first of a broad class of cell regulators, largely acting through autocrine and paracrine interactions which will be described herein. It was of similar significance in establishing the identity and unique roles of neurotrophic factors in the development and maintenance of the peripheral and central nervous systems. Finally, it contributed to many advances in the elaboration of cell surface receptor mechanisms and intracellular cell signaling. As such, it can be considered to be a "molecular Rosetta Stone". In this brief review, the highlights of these various studies are summarized, particularly as illustrated by their coverage in the 13 NGF international meetings that have been held since 1986.

Indexed as

AnimalsHumansNerve Growth FactorNerve Growth Factorcell signalingcentral nervous systemdevleopmentgrowth factorsneurotrophinsreceptors

Identifiers

PMID28587118
PMCPMC5485967
OpenAlexW2617290197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.