ReviewNutrients2017
Diet-Induced Low-Grade Metabolic Acidosis and Clinical Outcomes: A Review.
Review in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 7 syntheses or guidelines pooled it, 140 citations in OpenAlex.
- Effects of Potassium Citrate Supplementation on Bone Turnover Markers in Postmenopausal Women: A GRADE-Assessed Systematic Review, Meta-analysis and Trial Sequential Analysis.Calcified tissue international · 2026Pooled it
- Association between dietary acid load and risk of osteoporotic fractures in adults: a systematic review and meta-analysis of observational studies.BMC musculoskeletal disorders · 2025Pooled it
- Effects of the ketogenic diet on bone health: A systematic review.Frontiers in endocrinology · 2023Pooled it
- Dietary Acid Load and Bone Health: A Systematic Review and Meta-Analysis of Observational Studies.Frontiers in nutrition · 2022Pooled it
- Very-low-calorie ketogenic diet (VLCKD) in the management of metabolic diseases: systematic review and consensus statement from the Italian Society of Endocrinology (SIE).Journal of endocrinological investigation · 2019Pooled it
- Dietary Patterns in Relation to Low Bone Mineral Density and Fracture Risk: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2019Pooled it
- Animal versus plant protein and adult bone health: A systematic review and meta-analysis from the National Osteoporosis Foundation.PloS one · 2018Pooled it
- A Vegan Diet Is Associated with a Significant Reduction in Dietary Acid Load: Post Hoc Analysis of a Randomized Controlled Trial in Healthy Individuals.International journal of environmental research and public health · 2021Trial
- Trial
- Association of Urinary Citrate With Acid-Base Status, Bone Resorption, and Calcium Excretion in Older Men and Women.The Journal of clinical endocrinology and metabolism · 2018Trial
- Localized Intratumoral Ammonium Hydroxide Administration Demonstrates Changes in Tumor Architecture and Renal Response in a Murine Breast Cancer Xenograft Model.Current issues in molecular biology · 2026Article
- Dietary Acid Load Across Vegans, Lacto-Ovo-Vegetarians, Fish-Eaters, and Meat-Eaters, and Its Association with Body Mass Index: A Secondary Analysis from an Italian Survey (The INVITA Study).Foods (Basel, Switzerland) · 2026Article
- The association between dietary acid load and endometriosis: a case-control study.BMC women's health · 2026Article
- The Association Between Dietary Acid Load and Non-Alcoholic Fatty Liver Disease.Food science & nutrition · 2026Review
- Assessment of the acidifying potential of diet and sarcopenia in individuals 50 years of age or older: a cross-sectional study.BMC nutrition · 2026Article
- Ammonium Hydroxide Enhancement of Dietary Protein in High-Fat Diets Modulates Liver Metabolism Signaling in a Sex- and Age-Dependent Manner in C3H/HeJ Mice.International journal of molecular sciences · 2025Article
- Beyond Thirst: Influence of Bicarbonate Mineral Water on Cardiovascular Risk Factors, Gastrointestinal Function, and Liver Health.Food science & nutrition · 2025Review
- Tendency to acidosis or alkalosis: Which one is associated with coronary artery disease?Journal of cardiovascular and thoracic research · 2025Article
- Dietary acid load and its association with all-cause mortality, cardiovascular mortality, and events.Scientific reports · 2025Article
- Association Between Dietary Acid Load and Excess Weight in Adults: A Cross-Sectional Study.Nutrients · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low-grade metabolic acidosis is a condition characterized by a slight decrease in blood pH, within the range considered normal, and feeding is one of the main factors that may influence the occurrence of such a condition. The excessive consumption of acid precursor foods (sources of phosphorus and proteins), to the detriment of those precursors of bases (sources of potassium, calcium, and magnesium), leads to acid-base balance volubility. If this condition occurs in a prolonged, chronic way, low-grade metabolic acidosis can become significant and predispose to metabolic imbalances such as kidney stone formation, increased bone resorption, reduced bone mineral density, and the loss of muscle mass, as well as the increased risk of chronic diseases such as type 2 diabetes mellitus, hypertension, and non-alcoholic hepatic steatosis. Considering the increase in the number of studies investigating the influence of diet-induced metabolic acidosis on clinical outcomes, this review gathers the available evidence evaluating the association of this disturbance and metabolic imbalances, as well as related mechanisms. It is necessary to look at the western dietary pattern of most countries and the increasing incidence of non-comunicable diseases for the balance between fruit and vegetable intake and the appropriate supply of protein, mainly from animal sources, so that it does not exceed the daily recommendations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.