ArticleAnnals of internal medicine2017
Presence of Human Hepegivirus-1 in a Cohort of People Who Inject Drugs.
Article in Annals of internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01285050 (Interferon Alfa Sensitivity in HIV/HCV Coinfected Persons Before and After Antiretroviral Therapy), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Interferon Alfa Sensitivity in HIV/HCV Coinfected Persons Before and After Antiretroviral Therapy
Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
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- Metagenomic next generation sequencing of plasma RNA for diagnosis of unexplained, acute febrile illness in Uganda.PLoS neglected tropical diseases · 2024Article
- The Blood Virome: A new frontier in biomedical science.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024Review
- Long-Read Nanopore-Based Sequencing of Anelloviruses.Viruses · 2024Article
- Absence of pathogenic viruses in COVID-19 convalescent plasma.Transfusion · 2023Article
- Shared Autonomy to Reduce Sedentary Behavior Among Sit-Stand Desk Users in the United States and India: Web-Based Study.JMIR formative research · 2022Article
- The Second Human Pegivirus, a Non-Pathogenic RNA Virus with Low Prevalence and Minimal Genetic Diversity.Viruses · 2022Review
- The Abbott Pandemic Defense Coalition: a unique multisector approach adds to global pandemic preparedness efforts.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
- Plasma virome and the risk of blood-borne infection in persons with substance use disorder.Nature communications · 2021Article
- Highly multiplexed oligonucleotide probe-ligation testing enables efficient extraction-free SARS-CoV-2 detection and viral genotyping.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Article
- Highly multiplexed oligonucleotide probe-ligation testing enables efficient extraction-free SARS-CoV-2 detection and viral genotyping.bioRxiv : the preprint server for biology · 2020Article
- Evidence that the second human pegivirus (HPgV-2) is primarily a lymphotropic virus and can replicate independent of HCV replication.Emerging microbes & infections · 2020Article
- Epidemiological and Clinical Characteristics of Human Hepegivirus 1 Infection in Patients With Hepatitis C.Open forum infectious diseases · 2019Article
- A review of methods and databases for metagenomic classification and assembly.Briefings in bioinformatics · 2019Review
- Hepatitis C virus surveillance and identification of human pegivirus 2 in a large Cameroonian cohort.Journal of viral hepatitis · 2019Article
- Detection and Characterization of Human Pegivirus 2, Vietnam.Emerging infectious diseases · 2018Observational
- Development and Optimization of Metagenomic Next-Generation Sequencing Methods for Cerebrospinal Fluid Diagnostics.Journal of clinical microbiology · 2018Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNext-generation metagenomic sequencing (NGMS) has opened new frontiers in microbial discovery but has been clinically characterized in only a few settings.
objectiveTo explore the plasma virome of persons who inject drugs and to characterize the sensitivity and accuracy of NGMS compared with quantitative clinical standards.
designLongitudinal and cross-sectional studies.
settingA clinical trial (ClinicalTrials.gov: NCT01285050) and a well-characterized cohort study of persons who have injected drugs.
participantsPersons co-infected with hepatitis C virus (HCV) and HIV. MEASUREMENTS: Viral nucleic acid in plasma by NGMS and quantitative polymerase chain reaction (PCR).
resultsNext-generation metagenomic sequencing generated a total of 600 million reads, which included the expected HIV and HCV RNA sequences. HIV and HCV reads were consistently identified only when samples contained more than 10 000 copies/mL or IU/mL, respectively, as determined by quantitative PCR. A novel RNA virus, human hepegivirus-1 (HHpgV-1), was also detected by NGMS in 4 samples from 2 persons in the clinical trial. Through use of a quantitative PCR assay for HHpgV-1, infection was also detected in 17 (10.9%) of 156 members of a cohort of persons who injected drugs. In these persons, HHpgV-1 viremia persisted for a median of at least 4538 days and was associated with detection of other bloodborne viruses, such as HCV RNA and SEN virus D. LIMITATION: The medical importance of HHpgV-1 infection is unknown.
conclusionAlthough NGMS is insensitive for detection of viruses with relatively low plasma nucleic acid concentrations, it may have broad potential for discovery of new viral infections of possible medical importance, such as HHpgV-1. PRIMARY FUNDING SOURCE: National Institutes of Health.
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