ArticleSeizure2017
LGI1-antibody encephalitis is characterised by frequent, multifocal clinical and subclinical seizures.
Article in Seizure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Clinical Features and Therapeutic Effects of Anti-leucine-rich Glioma Inactivated 1 Encephalitis: A Systematic Review.Frontiers in neurology · 2021Pooled it
- Utility of the APEAnnals of clinical and translational neurology · 2026Article
- The electroclinical phenotype of epilepsy following autoimmune encephalitis.Epilepsy & behavior reports · 2026Article
- IgLON5 autoimmune antibodies activate Tau via neuronal hyperactivity.Science advances · 2026Article
- WONOEP XVII appraisal: The immunopathogenesis of epilepsy.Epilepsia · 2026Review
- The gut microbiome associated with LGI1-antibody encephalitis.Epilepsia · 2025Article
- Risk of Epilepsy and Factors Associated With Time to Seizure Remission in Anti-LGI1 Encephalitis: Long-Term Outcome in 236 Patients.Neurology(R) neuroimmunology & neuroinflammation · 2025Observational
- Ictal cold shiver caused by autoimmune limbic encephalitis: A case report and literature review.Epilepsy & behavior reports · 2025Article
- Distinctive seizure signature in the first video case-control study of a naturally-occurring feline autoimmune encephalitis model.Brain, behavior, and immunity · 2025Article
- Features of the clinical course of Autoimmune Encephalitis Associated with various antibodies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Observational
- Clinical features, cerebrospinal fluid changes, and prognosis in Chinese patients with autoimmune encephalitis.Acta neurologica Belgica · 2024Article
- Emerging Biomarkers for the Early Detection of Autoimmune Encephalitis: A Narrative Review.Cureus · 2024Review
- Peripherally-derived LGI1-reactive monoclonal antibodies cause epileptic seizures in vivo.Brain : a journal of neurology · 2024Article
- A Case of Anti-Leucine-Rich Glioma-Inactivated Protein 1 (Anti-LGI1) Limbic Encephalitis With Normal Imaging.Cureus · 2024Article
- Seizure-Related Falls and Near Falls in LGI1-IgG Autoimmune Encephalitis.Neurology. Clinical practice · 2024Article
- Autoimmune encephalitis in a resource-limited public health setting: a case series analysis.Arquivos de neuro-psiquiatria · 2024Article
- Autoimmune encephalitis: recent clinical and biological advances.Journal of neurology · 2023Article
- GAD65 Antibody-Associated Epilepsy.Medicina (Kaunas, Lithuania) · 2023Review
- Comparative Effects of Domain-Specific Human Monoclonal Antibodies Against LGI1 on Neuronal Excitability.Neurology(R) neuroimmunology & neuroinflammation · 2023Article
- Important Clues for the Diagnosis of Anti-LGI1-Antibody Autoimmune Encephalitis: A Case Report.Cureus · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo describe clinical and electrographic characteristics of seizures LGI1-antibody encephalitis, and their correlations with two-year outcomes.
methodsVideo-electroencephalography recordings were performed on a cohort of 16 consecutive patients with LGI1-antibodies from two UK neuroscience-centers over five-years.
resultsFrom 14 of 16 patients (13 males; age-range 53-92years), 86 faciobrachial dystonic seizures were recorded at a median frequency of 0.4 per hour (range 0.1-9.8), and ictal EEG changes accompanied 5/86 events. In addition, 11/16 patients showed 53 other seizures - subclinical (n=18), motor (n=16), or sensory (n=19) - at a median of 0.1 per hour (range 0.1-2) associated with temporal and frontal discharges. The sensory events were most commonly thermal sensations or body-shuddering, and the motor events were frequently automatisms or vocalisations. Furthermore, multifocal interictal epileptiform discharges, from temporal, frontal and parietal regions, and interictal slow-wave activity were observed in 25% and 69% of patients, respectively. Higher observed seizure frequency correlated with poorer functional recovery at two-years (p=0.001).
conclusionsMultiple frequent seizure semiologies, in addition to numerous subclinical seizures and interictal epileptiform discharges, are hallmarks of LGI1-antibody encephalitis. High overall seizure frequency may predict more limited long-term recovery. These observations should encourage closer monitoring and proactive treatment of seizure activity in these patients.
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