ArticleJournal of experimental botany2017
The Arabidopsis Cys2/His2 zinc finger transcription factor ZAT18 is a positive regulator of plant tolerance to drought stress.
Article in Journal of experimental botany, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.
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73 citing papers in PubMed, 1 synthesis or guideline pooled it, 158 citations in OpenAlex.
- Deciphering the molecular basis of abiotic stress response in cucumber (Cucumis sativus L.) using RNA-Seq meta-analysis, systems biology, and machine learning approaches.Scientific reports · 2023Pooled it
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- Quantitative trait loci associated with drought stress tolerance in wheat primed with zinc oxide nanoparticles at seed germination and seedling stages.Scientific reports · 2026Article
- The Structure, Classification, Functional Diversity and Regulatory Mechanism of Plant C2H2 Transcription Factors.Biology · 2026Review
- Engineering resilient roses: molecular insights into biotic and abiotic stress adaptation.Horticulture research · 2026Article
- Genome-Wide Identification and Analysis of Plant Cysteine Oxidase (International journal of molecular sciences · 2026Article
- PpZAT12 from a native Kentucky bluegrass (Poa pratensis L.) confers drought tolerance through regulating antioxidant defense system and multiple metabolic pathways.BMC plant biology · 2026Article
- Functional characterization of four soybean C2H2 zinc-finger genes inPlant signaling & behavior · 2025Article
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- Rice Transcription Factor HSTL Regulates Plant Height and Salt Stress Response by Modulating Gibberellin Homeostasis.Rice (New York, N.Y.) · 2025Article
- T-DNAreader: fast and precise identification of T-DNA insertion sites in plant genomes using RNA sequencing data.Genome biology · 2025Article
- Identification of the Q-type ZFP gene family in Triticeaes and drought stress expression analysis in common wheat.Genetica · 2025Article
- Hierarchical Regulatory Networks Reveal Conserved Drivers of Plant Drought Response at the Cell-Type Level.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Integrative physiological and transcriptomic analysis provides insights on the molecular basis of ABA-enhanced drought tolerance in pear (Pyrus betulaefolia).BMC plant biology · 2025Article
- TaSnRK3.23B, a CBL-interacting protein kinase of wheat, confers drought stress tolerance by promoting ROS scavenging in Arabidopsis.BMC plant biology · 2025Article
- The nuclear exosome subunit HEN2 acts independently of the core exosome to assist transcription in Arabidopsis.Plant physiology · 2024Article
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- Dissecting the temporal genetic networks programming soybean embryo development from embryonic morphogenesis to post-germination.Plant cell reports · 2024Article
- Comprehensive analysis of PLATZ family genes and their responses to abiotic stresses in Barley.BMC plant biology · 2024Article
- ZmLSD1 Enhances Salt Tolerance by Regulating the Expression ofPlants (Basel, Switzerland) · 2024Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental stress poses a global threat to plant growth and reproduction, especially drought stress. Zinc finger proteins comprise a family of transcription factors that play essential roles in response to various abiotic stresses. Here, we found that ZAT18 (At3g53600), a nuclear C2H2 zinc finger protein, was transcriptionally induced by dehydration stress. Overexpression (OE) of ZAT18 in Arabidopsis improved drought tolerance while mutation of ZAT18 resulted in decreased plant tolerance to drought stress. ZAT18 was preferentially expressed in stems, siliques, and vegetative rosette leaves. Subcellular location results revealed that ZAT18 protein was predominantly localized in the nucleus. ZAT18 OE plants exhibited less leaf water loss, lower content of reactive oxygen species (ROS), higher leaf water content, and higher antioxidant enzyme activities after drought treatment when compared with the wild type (WT). RNA sequencing analysis showed that 423 and 561 genes were transcriptionally modulated by the ZAT18 transgene before and after drought treatment, respectively. Pathway enrichment analysis indicated that hormone metabolism, stress, and signaling were over-represented in ZAT18 OE lines. Several stress-responsive genes including COR47, ERD7, LEA6, and RAS1, and hormone signaling transduction-related genes including JAZ7 and PYL5 were identified as putative target genes of ZAT18. Taken together, ZAT18 functions as a positive regulator and plays a crucial role in the plant response to drought stress.
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