ArticlePloS one2017
Oncologic and surgical outcomes in colorectal cancer patients with liver cirrhosis: A propensity-matched study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Colorectal Surgery in Patients with Liver Cirrhosis: A Systematic Review.World journal of surgery · 2023Pooled it
- Does liver cirrhosis affect the surgical outcome of primary colorectal cancer surgery? A meta-analysis.World journal of surgical oncology · 2021Pooled it
- Meta-analysis of short- and long-term outcomes after pure laparoscopic versus open liver surgery in hepatocellular carcinoma patients.Surgical endoscopy · 2019Pooled it
- Elective colorectal surgery in those with cirrhosis: a population-based study assessing practice patterns and patient outcomes.Journal of the Canadian Association of Gastroenterology · 2026Article
- Risk factors for infectious complications and postoperative outcomes of colorectal cancer patients with liver cirrhosis: a multicenter retrospective study.Surgery today · 2026Article
- Postoperative Survival Analysis of Elective Colorectal Cancer Surgery with Liver Cirrhosis: A Propensity-Matched Study.Current oncology (Toronto, Ont.) · 2026Article
- The association between cirrhosis and outcomes among female patients undergoing surgery for breast cancer in Ontario: a population-based study.Breast cancer research and treatment · 2025Article
- Elevated expression patterns of P-element Induced Wimpy Testis (PIWI) transcripts are potential candidate markers for Hepatocellular Carcinoma.Cancer biomarkers : section A of Disease markers · 2024Article
- Colorectal Cancer in Individuals with Cirrhosis: A Population-Based Study Assessing Practice Patterns, Outcomes, and Predictors of Survival.Current oncology (Toronto, Ont.) · 2023Article
- Mortality following elective and emergency colectomy in patients with cirrhosis: a population-based cohort study from England.International journal of colorectal disease · 2022Article
- Clinical Characteristics of Primary Repair for Perforated Peptic Ulcer: 10-Year Experience in a Single Center.Journal of clinical medicine · 2021Article
- Metastases can occur in cirrhotic livers with patent portal veins.Diagnostic pathology · 2021Article
- Gastrointestinal Cancers and Liver Cirrhosis: Implications on Treatments and Prognosis.Frontiers in oncology · 2021Review
- Muscle-Invasive Bladder Cancer in Patients with Liver Cirrhosis: A Review of Pertinent Considerations.Bladder cancer (Amsterdam, Netherlands) · 2021Review
- Article
- Hypertriglyceridaemia as a risk factor for critical care admission in acute pancreatitis: A prospective study.Clinical nutrition ESPEN · 2020Observational
- The prognoses and postoperative outcomes of patients with both colorectal cancer and liver cirrhosis based on a nationwide cohort in Korea.Annals of surgical treatment and research · 2020Article
- Quantitative magnetic resonance imaging predicts individual future liver performance after liver resection for cancer.PloS one · 2020Observational
- NOD-like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD.Hepatology (Baltimore, Md.) · 2019Article
- Familial and non-familial risk factors associated with colorectal cancer survival in young and middle-aged patients.International journal of colorectal disease · 2019Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The management of colorectal cancer in patients with liver cirrhosis requires a thorough understanding of both diseases. This study evaluated the effect of liver cirrhosis on oncologic and surgical outcomes and prognostic factors in colorectal cancer patients. Fifty-five consecutive colorectal cancer patients with liver cirrhosis underwent colorectal resection (LC group). Using a prospectively maintained database, these patients were matched 1:4 using propensity scoring with R programming language, package "MatchIt" and "optmatch" by sex, age, cancer location, and tumor stage with 220 patients without liver cirrhosis (non-LC group), resulting in 275 patients. The 5-year overall survival (OS) was significantly worse in the LC group than in the non-LC group (46.7% vs. 76.2% respectively, P < 0.001); however, the 5-year proportion of recurrence free (PRF) rates were similar (73.1% vs. 84.5% respectively, P = 0.094). On multivariate analysis of the LC group, tumor-node-metastasis (TNM) stage ≥III disease, venous invasion, and a model for end-stage liver disease plus serum sodium (MELD-Na) score >10 were prognostic factors for OS. However, the OS was not different between the LC group with MELD-Na score ≤10 and the non-LC group (5-year OS rate, TNM stage ≤II, 85.7 vs 89.5%, p = 0.356; TNM stage ≥III, 41.1 vs 66.2%, p = 0.061). Colorectal cancer patients with liver cirrhosis have poorer OS compared to those without liver cirrhosis; however, the PRF rates are similar. It might be due to the mortality from the liver, and surgical treatment should be actively considered for patients with MELD-Na score <10.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.