Evidence map›Paper›PMID 28586358›Full record

ArticlePloS one2017

Parental alcohol use and risk of behavioral and emotional problems in offspring.

Liam Mahedy, Gemma Hammerton, Alison Teyhan, Alexis C Edwards, Kenneth S Kendler, Simon C Moore, Matthew Hickman, John Macleod, Jon Heron

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Liam MahedySchool of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.ORCID http://orcid.org/0000-0001-5417-6595
Gemma HammertonSchool of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
Alison TeyhanSchool of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
Alexis C EdwardsDepartment of Psychiatry and School of Medicine, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America.
Kenneth S KendlerDepartment of Psychiatry and School of Medicine, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America.
Simon C MooreSchool of Dentistry, College of Biomedical and Life Science, Cardiff University, Cardiff, United Kingdom.
Matthew HickmanSchool of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
John MacleodSchool of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
Jon HeronSchool of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
University of Bristol · GBVirginia Commonwealth University · USCardiff University · GB

Funding

Pathways to Alcohol Use Disorders in ALSPAC: A Genetic-Developmental StudyR01AA018333 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M, KENDLER, KENNETH SEEDMAN · 2010 to 2014
$2.8M
Genetic influences on developmental heterogeneity of alcohol use disorderK01AA021399 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI EDWARDS, ALEXIS C · 2012 to 2016
$707k
Medical Research Council G0800612Medical Research Council G0802736Medical Research Council MC_PC_15018Medical Research Council MR/K006525/1Medical Research Council MR/L022206/1NIAAA NIH HHS K01 AA021399NIAAA NIH HHS R01 AA018333Wellcome Trust
6 · The paper itself

Abstract

objectiveThe majority of studies that have examined parental alcohol use and offspring outcomes have either focused on exposure in the antenatal period or from clinical populations. This study sought to examine proximal and distal associations between parental alcohol use and offspring conduct problems and depressive symptoms in a population birth cohort.

methodsWe used prospective data from a large UK based population cohort (ALSPAC) to investigate the association between parental alcohol use, measured in units, (assessed at ages 4 and 12 years) with childhood conduct trajectories, (assessed on six occasions from 4 to 13.5 years, n = 6,927), and adolescent depressive symptoms (assessed on four occasions from ~13 to ~18 years, n = 5,539). Heavy drinking was defined as ≥21 units per week in mothers and partners who drank 4+ units daily.

resultsWe found little evidence to support a dose response association between parental alcohol use and offspring outcomes. For example, we found insufficient evidence to support an association between maternal alcohol use at age 4 years and childhood conduct problems (childhood limited: OR = 1.00, 95% CI = .99, 1.01; adolescent onset: OR = 0.99, 95% CI = .98, 1.00; and early-onset persistent: OR = 0.99, 95% CI = .98, 1.00) per 1-unit change in maternal alcohol use compared to those with low levels of conduct problems. We also found insufficient evidence to support an association between maternal alcohol use at age 4 years and adolescent depressive symptoms (intercept: b = .001, 95% CI = -.01, .01, and slope: b = .003, 95% CI = -.03, .03) per 1-unit change in maternal alcohol use. Results remained consistent across amount of alcohol consumed (i.e., number of alcohol units or heavy alcohol use), parent (maternal self-reports or maternal reports of partner's alcohol use), and timing of alcohol use (assessed at age 4 or age 12 years).

conclusionsThere is no support for an association between parental alcohol use during childhood and conduct and emotional problems during childhood or adolescence.

Indexed as

AdolescentAdultAlcohol DrinkingChildChild BehaviorChild, PreschoolDepressionFemaleHumansMaleMothersParentsPregnancyPrenatal Exposure Delayed EffectsRisk Factors

Identifiers

PMID28586358
PMCPMC5460848
OpenAlexW2622471851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.