Evidence map›Paper›PMID 28586243›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2017

Falls, Functioning, and Disability Among Women With Persistent Symptoms of Chemotherapy-Induced Peripheral Neuropathy.

Kerri M Winters-Stone, Fay Horak, Peter G Jacobs, Phoebe Trubowitz, Nathan F Dieckmann, Sydnee Stoyles, Sara Faithfull

5 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 197 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
197citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04558034 naterminatednot on this mapstarted 2020, after this paper: background citation

The Use of Cryotherapy to Prevent Paclitaxel-induced Peripheral Neuropathy and Nail Changes in Women With Breast Cancer

TypeinterventionalSponsorParkview HealthRan2020 to 2021Enrolled14ConditionsCryotherapy Effect, Peripheral Neuropathy, Nail ToxicityArmscryotherapy
NCT04920097 nacompletednot on this mapstarted 2021, after this paper: background citation

Auricular Point Acupressure to Manage Chemotherapy Induced Neuropathy

TypeinterventionalSponsorThe University of Texas Health Science Center, HoustonRan2021 to 2026Enrolled238ConditionsChemotherapy-induced NeuropathyArmsIn-person training for seed placement and APA, Virtual training for seed placement and APA, Usual Care, Post-training zoom session for seed placement and APA coaching
NCT04959929 nacompletednot on this mapstarted 2023, after this paper: background citation

Wearable Focal Vibration for Chemotherapy-Induced Peripheral Neuropathy

TypeinterventionalSponsorUniversity of OklahomaRan2023 to 2025Enrolled13ConditionsChemotherapy-induced Peripheral NeuropathyArmsFocal vibration therapy
NCT06610617 nacompletednot on this mapstarted 2024, after this paper: background citation

Neuromodulation of Central Sensory Integration to Improve Postural Control: A Pilot Study in Older Women With Breast Cancer

TypeinterventionalSponsorUniversity of PittsburghRan2024 to 2025Enrolled48ConditionsSurvivorship, Quality of Life, Cognitive Deficits, MildArmstranscranial direct current stimulation (tDCS), Sham tDCS
NCT06834685 narecruitingnot on this mapstarted 2025, after this paper: background citation

Evaluating Laser Photobiomodulation for the Treatment of Neuropathic Pain in Chemotherapy-induced Peripheral Neuropathy: a Randomized, Non-comparative, Placebo-controlled, Single-blinded, Phase II Clinical Trial in Cancer Patients

TypeinterventionalSponsorInstitut du Cancer de Montpellier - Val d'AurelleRan2025 to 2028Enrolled70ConditionsCancer Survivors, Peripheral Neuropathic PainArmsPhotobiomodulation sessions
3 · Its place in the literature

Who cites it

197 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  5. The effects of exercise on chemotherapy-induced peripheral neuropathy symptoms in cancer patients: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Pooled it
  6. Pooled it
  7. Falls in older adults with cancer: an updated systematic review of prevalence, injurious falls, and impact on cancer treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Pooled it
  8. Pooled it
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  14. Effects on chemotherapy-induced peripheral neuropathy by moderate strength training in combination with whole-body vibration in breast cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
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  20. Efficacy of combined hand exercise intervention in patients with chemotherapy-induced peripheral neuropathy: a pilot randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Trial

137 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Kerri M Winters-StoneKerri M. Winters-Stone, Fay Horak, Peter G. Jacobs, Phoebe Trubowitz, Nathan F. Dieckmann, and Sydnee Stoyles, Oregon Health & Science University, Portland, OR; and Sara Faithfull, University of Surrey, Guildford, Surrey, United Kingdom.
Fay HorakKerri M. Winters-Stone, Fay Horak, Peter G. Jacobs, Phoebe Trubowitz, Nathan F. Dieckmann, and Sydnee Stoyles, Oregon Health & Science University, Portland, OR; and Sara Faithfull, University of Surrey, Guildford, Surrey, United Kingdom.
Peter G JacobsKerri M. Winters-Stone, Fay Horak, Peter G. Jacobs, Phoebe Trubowitz, Nathan F. Dieckmann, and Sydnee Stoyles, Oregon Health & Science University, Portland, OR; and Sara Faithfull, University of Surrey, Guildford, Surrey, United Kingdom.
Phoebe TrubowitzKerri M. Winters-Stone, Fay Horak, Peter G. Jacobs, Phoebe Trubowitz, Nathan F. Dieckmann, and Sydnee Stoyles, Oregon Health & Science University, Portland, OR; and Sara Faithfull, University of Surrey, Guildford, Surrey, United Kingdom.
Nathan F DieckmannKerri M. Winters-Stone, Fay Horak, Peter G. Jacobs, Phoebe Trubowitz, Nathan F. Dieckmann, and Sydnee Stoyles, Oregon Health & Science University, Portland, OR; and Sara Faithfull, University of Surrey, Guildford, Surrey, United Kingdom.
Sydnee StoylesKerri M. Winters-Stone, Fay Horak, Peter G. Jacobs, Phoebe Trubowitz, Nathan F. Dieckmann, and Sydnee Stoyles, Oregon Health & Science University, Portland, OR; and Sara Faithfull, University of Surrey, Guildford, Surrey, United Kingdom.
Sara FaithfullKerri M. Winters-Stone, Fay Horak, Peter G. Jacobs, Phoebe Trubowitz, Nathan F. Dieckmann, and Sydnee Stoyles, Oregon Health & Science University, Portland, OR; and Sara Faithfull, University of Surrey, Guildford, Surrey, United Kingdom.

Funding

Understanding the origins of rapid recurrence of pancreatic cancer after resectionP30CA069533 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Luiz Eduardo Bertassoni · 1997 to 2026
$60.5M
Preventing falls after cancer: Tai chi vs. strength trainingR01CA163474 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI WINTERS-STONE, KERRI M · 2012 to 2016
$3.0M
NCI NIH HHS P30 CA069533NCI NIH HHS R01 CA163474
6 · The paper itself

Abstract

Purpose Chemotherapy-induced peripheral neuropathy (CIPN) may persist after treatment ends and may lead to functional decline and falls. This study compared objective and self-report measures of physical function, gait patterns, and falls between women cancer survivors with and without symptoms of CIPN to identify targets for functional rehabilitation. Methods A secondary data analysis of 512 women cancer survivors (age, 62 ± 6 years; time since diagnosis, 5.8 ± 4.1 years) categorized and compared women self-reporting symptoms of CIPN (CIPN+) with asymptomatic women (CIPN-) on the following: maximal leg strength, timed chair stand, physical function battery, gait characteristics (speed; step number, rate, and length; base of support), self-report physical function and disability, and falls in the past year. Results After an average of 6 years after treatment, 47% of women still reported symptoms of CIPN. CIPN+ had significantly worse self-report and objectively measured function than did CIPN-, with the exception of maximal leg strength and base of support during a usual walk. Gait was slower among CIPN+, with those women taking significantly more, but slower and shorter, steps than did CIPN- (all P < .05). CIPN+ reported significantly more disability and 1.8 times the risk of falls compared with CIPN- ( P < .0001). Increasing symptom severity was linearly associated with worsening function, increasing disability, and higher fall risk (all P < .05). Conclusion This work makes a significant contribution toward understanding the functional impact of CIPN symptoms on cancer survivors. Remarkably, 47% of women in our sample had CIPN symptoms many years after treatment, together with worse function, greater disability, and more falls. CIPN must be assessed earlier in the clinical pathway, and strategies to limit symptom progression and to improve function must be included in clinical and survivorship care plans.

Indexed as

Accidental FallsDisability EvaluationAgedAntineoplastic AgentsExercise TestFemaleGaitHumansLower ExtremityMiddle AgedMuscle, SkeletalMuscle StrengthNeoplasmsPeripheral Nervous System DiseasesSelf ReportSeverity of Illness IndexAntineoplastic Agents

Identifiers

PMID28586243
PMCPMC5549452

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.