Evidence map›Paper›PMID 28586110›Full record

ArticleChembiochem : a European journal of chemical biology2017

Molecular Containers Bind Drugs of Abuse in Vitro and Reverse the Hyperlocomotive Effect of Methamphetamine in Rats.

Shweta Ganapati, Stephanie D Grabitz, Steven Murkli, Flora Scheffenbichler, Maíra I Rudolph, Peter Y Zavalij, Matthias Eikermann, Lyle Isaacs

Abstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
  2. Acyclic cucurbituril as sequestrant for acetaminophen.Chemical communications (Cambridge, England) · 2026
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  4. Article
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  6. Article
  7. Acyclic cucurbit[Beilstein journal of organic chemistry · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Goofball Polypharmacy.The Journal of pharmacology and experimental therapeutics · 2024
    Article
  14. Article
  15. An overview of the SAMPL8 host-guest binding challenge.Journal of computer-aided molecular design · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. In Vitro and In Vivo Sequestration of Phencyclidine by MeChemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Shweta GanapatiDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA.
Stephanie D GrabitzDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Steven MurkliDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA.
Flora ScheffenbichlerDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Maíra I RudolphDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Peter Y ZavalijDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA.
Matthias EikermannDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Lyle IsaacsDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA.ORCID 0000-0002-4079-332X
Harvard University · USUniversity of Maryland, College Park · US

Funding

Acyclic Cucurbit n uril Molecular Containers for Drug Solubilization and DeliveryR01CA168365 · NCI · UNIV OF MARYLAND, COLLEGE PARK · PI BRIKEN, VOLKER, ISAACS, LYLE D · 2013 to 2017
$1.9M
NCI NIH HHS R01 CA168365
6 · The paper itself

Abstract

We measured the affinity of five molecular container compounds (calabadions 1 and 2, CB[7], sulfocalix[4]arene, and HP-β-CD) toward seven drugs of abuse in homogenous aqueous solution at physiological pH by various methods (

Indexed as

2-Hydroxypropyl-beta-cyclodextrinAnimalsBridged-Ring CompoundsCalixarenesCrystallography, X-RayCucurbit(n)urilsFentanylHeterocyclic Compounds, 4 or More RingsIllicit DrugsImidazolesLocomotionMacrocyclic CompoundsMaleMethamphetaminePhenolsRats, Sprague-Dawley2-Hydroxypropyl-beta-cyclodextrinBridged-Ring Compoundscalabadion 1calabadion 2Calixarenescucurbit(7)urilCucurbit(n)urilsFentanylHeterocyclic Compounds, 4 or More RingsIllicit DrugsImidazolesMacrocyclic CompoundsMethamphetaminePhenolsp-sulfonatocalix(4)areneSequestering AgentsSulfonic Acidscalabadiondrugs of abusemethamphetaminemolecular containerreversal agent

Identifiers

PMID28586110
PMCPMC5570556
OpenAlexW2624514819

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.