ArticleMolecular medicine reports2017
Small protein A and phospholipase D immunization serves a protective role in a mouse pneumonia model of Acinetobacter baumannii infection.
Article in Molecular medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Comparison of Immunoprotective Efficacy of Six Antigenic Proteins ofPathogens (Basel, Switzerland) · 2026Article
- Identification of multiple Acinetobacter baumannii protein antigens as targets for potential immunotherapies using a novel protein microarray screening approach.PLoS pathogens · 2026Article
- mRNA-LNP Vaccines Targeting SmpA-PLD and OmpK-Omp22 Induce Protective Immunity AgainstVaccines · 2025Article
- Non-antibiotic prevention and treatment againstFrontiers in microbiology · 2023Review
- In Silico Analyses of Extracellular Proteins ofIranian journal of pharmaceutical research : IJPR · 2022Article
- Facing the challenges of multidrug-resistantHuman vaccines & immunotherapeutics · 2021Article
- Phylogenomic Characterization of a NovelmSystems · 2021Article
- Recent Advances in the Pursuit of an EffectivePathogens (Basel, Switzerland) · 2020Review
- Outcomes and prognostic factors of tigecycline treatment for hospital-acquired pneumonia involving multidrug-resistantThe Journal of international medical research · 2020Article
- Expression pattern of soluble triggering receptor expressed on myeloid cells-1 in mice withJournal of thoracic disease · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acinetobacter baumannii is an important pathogen that primarily causes hospital-acquired pneumonia. The present study sought to investigate whether small protein A (SmpA) and phospholipase D (PLD) are potential candidates for protective immunity against infection with A. baumannii. Mice immunized with the fusion proteins histidine (His)‑SmpA and His‑PLD exhibited a specific immunoglobulin G response. In a pneumonia model, active and passive immunization against SmpA and PLD protected mice from A. baumannii infection. The protection was demonstrated by a markedly improved survival rate, and reduced pulmonary bacterial load, infiltration and cytokine levels in the broncho‑alveolar lavage fluid and the serum, although a combination of the two antigens did not provide improved protection compared with immunization with the individual antigens alone. In conclusion, it was identified that SmpA and PLD are highly immunogenic proteins, and potential antigen candidates for the development of effective vaccines or to prepare antisera to mitigate A. baumannii infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.