Evidence map›Paper›PMID 28585944›Full record

ReviewChemical Society reviews2017

Cellular uptake of nanoparticles: journey inside the cell.

Shahed Behzadi, Vahid Serpooshan, Wei Tao, Majd A Hamaly, Mahmoud Y Alkawareek, Erik C Dreaden, Dennis Brown, Alaaldin M Alkilany, Omid C Farokhzad, Morteza Mahmoudi

Abstract readReview
In one paragraph

Review in Chemical Society reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 889 papers.

0numbers the graph read from it
0cells of the map it votes in
889citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

889 citing papers in PubMed.

  1. Review
  2. Article
  3. Intracellular Delivery of Hydrophilic Glycans Using Superchaotropic Clusters.Angewandte Chemie (International ed. in English) · 2026
    Article
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  5. Review
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  11. Review
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829 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shahed BehzadiCenter for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. ofarokhzad@bwh.harvard.edu mmahmoudi@bwh.harvard.edu.
Vahid Serpooshan
Wei Tao
Majd A Hamaly
Mahmoud Y Alkawareek
Erik C Dreaden
Dennis Brown
Alaaldin M Alkilany
Omid C Farokhzad
Morteza Mahmoudi

Funding

The Development of Clinical Grade, Targeted Magnetic NanoparticlesU54CA151884 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2010 to 2014
$11.3M
Development of FcRn-Targeted Nanoparticles for Efficient Oral Delivery of InsulinR01EB015419 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI FAROKHZAD, OMID C, KARNIK, ROHIT N · 2012 to 2015
$2.8M
NCI NIH HHS U54 CA151884NIBIB NIH HHS R01 EB015419
6 · The paper itself

Abstract

Nanoscale materials are increasingly found in consumer goods, electronics, and pharmaceuticals. While these particles interact with the body in myriad ways, their beneficial and/or deleterious effects ultimately arise from interactions at the cellular and subcellular level. Nanoparticles (NPs) can modulate cell fate, induce or prevent mutations, initiate cell-cell communication, and modulate cell structure in a manner dictated largely by phenomena at the nano-bio interface. Recent advances in chemical synthesis have yielded new nanoscale materials with precisely defined biochemical features, and emerging analytical techniques have shed light on nuanced and context-dependent nano-bio interactions within cells. In this review, we provide an objective and comprehensive account of our current understanding of the cellular uptake of NPs and the underlying parameters controlling the nano-cellular interactions, along with the available analytical techniques to follow and track these processes.

Indexed as

Biochemical PhenomenaBiological TransportCell CommunicationHumansNanoparticles

Identifiers

PMID28585944
PMCPMC5593313

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.