ArticleJournal of applied toxicology : JAT2017
A physiologically based pharmacokinetic model of vitamin D.
Article in Journal of applied toxicology : JAT, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Serum Vitamin D: Correlates of Baseline Concentration and Response to Supplementation in VITAL-DKD.The Journal of clinical endocrinology and metabolism · 2022Trial
- The Effect of Vitamin DInternational journal of environmental research and public health · 2020Trial
- Novel Approach for the Approximation of Vitamin DPharmaceutics · 2023Article
- Position Statement: Vitamin D Intake to Prevent Osteoporosis and Fracture in Adults.Journal of bone metabolism · 2022Article
- Physiologically Based Pharmacokinetic Modeling of Vitamin DDrug metabolism and disposition: the biological fate of chemicals · 2022Article
- Bioavailability by design - Vitamin DNanomedicine : nanotechnology, biology, and medicine · 2022Article
- Treatment of Vitamin D Deficiency with Calcifediol: Efficacy and Safety Profile and Predictability of Efficacy.Nutrients · 2022Review
- Personalise vitamin DCPT: pharmacometrics & systems pharmacology · 2021Article
- Vitamin D Sources, Metabolism, and Deficiency: Available Compounds and Guidelines for Its Treatment.Metabolites · 2021Review
- Vitamin D Metabolism and Guidelines for Vitamin D Supplementation.The Clinical biochemist. Reviews · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Despite the plethora of studies discussing the benefits of vitamin D on physiological functioning, few mathematical models of vitamin D predict the response of the body on low-concentration supplementation of vitamin D under sunlight-restricted conditions. This study developed a physiologically based pharmacokinetic (PBPK) model utilizing published human data on the metabolic cascade of orally derived, low-concentration (placebo, 5 μg and 10 μg) supplementation of vitamin D over the course of 28 days in the absence of sunlight. Vitamin D and its metabolites are highly lipophilic and binding assays of these compounds in serum may not account for binding by lipids and additional proteins. To compensate for the additional bound amounts, this study allowed the effective adipose-plasma partition coefficient to vary dynamically with the concentration of each compound in serum utilizing the Hill equation for binding. Through incorporating the optimized parameters with the adipose partition coefficient adaptation to the PBPK model, this study was able to fit serum concentration data for circulating vitamin D at all three supplementation concentrations within confidence intervals of the data. Copyright © 2017 John Wiley & Sons, Ltd.
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