ReviewAdvanced healthcare materials2017
Bioinspired Collagen Scaffolds in Cranial Bone Regeneration: From Bedside to Bench.
Review in Advanced healthcare materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Polyetheretherketone (PEEK) in Cranial Vault Reconstruction: A Review of Alloplastic Materials, Clinical Performance, and Institutional Experience.Bioengineering (Basel, Switzerland) · 2026Article
- Calvarial Bone Defects Heal Better in Short-Term Ovariectomized Rats Compared to Healthy Rats.Journal of musculoskeletal & neuronal interactions · 2025Article
- Regenerative potential of biopolymers - calcium phosphate osteogenic composites in the healing of an experimental defect of the parietal bone.Biomaterials and biosystems · 2025Article
- Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration.Advanced therapeutics · 2025Article
- Correlating Material Properties to Osteoprotegerin Expression on Nanoparticulate Mineralized Collagen Glycosaminoglycan Scaffolds.Advanced healthcare materials · 2024Article
- Modulating Temporospatial Phosphate Equilibrium by Nanoparticulate Mineralized Collagen Materials Induces Osteogenesis via PiT-1 and PiT-2.Advanced healthcare materials · 2023Article
- Functionalization of biomimetic mineralized collagen for bone tissue engineering.Materials today. Bio · 2023Review
- Analysis of the Robotic-Based In Situ Bioprinting Workflow for the Regeneration of Damaged Tissues through a Case Study.Bioengineering (Basel, Switzerland) · 2023Article
- Osteoprotegerin-eluting nanoparticulate mineralized collagen scaffolds improve skull regeneration.Biomaterials advances · 2023Article
- 3D-Printed Flat-Bone-Mimetic Bioceramic Scaffolds for Cranial Restoration.Research (Washington, D.C.) · 2023Article
- A Narrative Review of Cell-Based Approaches for Cranial Bone Regeneration.Pharmaceutics · 2022Review
- Biphasic mineralized collagen-based composite scaffold for cranial bone regeneration in developing sheep.Regenerative biomaterials · 2022Article
- β-Catenin Limits Osteogenesis on Regenerative Materials in a Stiffness-Dependent Manner.Advanced healthcare materials · 2021Article
- Biomaterials with structural hierarchy and controlled 3D nanotopography guide endogenous bone regeneration.Science advances · 2021Article
- [The latest study on biomimetic mineralized collagen-based bone materials for pediatric skull regeneration and repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2021Review
- Stiffness of Nanoparticulate Mineralized Collagen Scaffolds Triggers Osteogenesis via Mechanotransduction and Canonical Wnt Signaling.Macromolecular bioscience · 2021Article
- Microporosities in 3D-Printed Tricalcium-Phosphate-Based Bone Substitutes Enhance Osteoconduction and Affect Osteoclastic Resorption.International journal of molecular sciences · 2020Article
- Injectable BMP-2 gene-activated scaffold for the repair of cranial bone defect in mice.Stem cells translational medicine · 2020Article
- Optimizing an Injectable Composite Oxygen-Generating System for Relieving Tissue Hypoxia.Frontiers in bioengineering and biotechnology · 2020Article
- Osteoprotegerin reduces osteoclast resorption activity without affecting osteogenesis on nanoparticulate mineralized collagen scaffolds.Science advances · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Calvarial defects are common reconstructive dilemmas secondary to a variety of etiologies including traumatic brain injury, cerebrovascular disease, oncologic resection, and congenital anomalies. Reconstruction of the calvarium is generally undertaken for the purposes of cerebral protection, contour restoration for psychosocial well-being, and normalization of neurological dysfunction frequently found in patients with massive cranial defects. Current methods for reconstruction using autologous grafts, allogeneic grafts, or alloplastic materials have significant drawbacks that are unique to each material. The combination of wide medical relevance and the need for a better clinical solution render defects of the cranial skeleton an ideal target for development of regenerative strategies focused on calvarial bone. With the improved understanding of the instructive properties of tissue-specific extracellular matrices and the advent of precise nanoscale modulation in materials science, strategies in regenerative medicine have shifted in paradigm. Previously considered to be simple carriers of stem cells and growth factors, increasing evidence exists for differential materials directing lineage specific differentiation of progenitor cells and tissue regeneration. In this work, we review the clinical challenges for calvarial reconstruction, the anatomy and physiology of bone, and extracellular matrix-inspired, collagen-based materials that have been tested for in vivo cranial defect healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.