ArticleMolecular neurobiology2018
A Possible Anti-Inflammatory Effect of Proline in the Brain Cortex and Cerebellum of Rats.
Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Pooled it
- Butylated Hydroxytoluene (BHT) and p-Coumaric Acid Conjugates of Dipeptide Proline and GABA as Multi-Functional Agents with High Pharmacological Potential.Molecules (Basel, Switzerland) · 2026Article
- Nutritional modulation of oxaliplatin-induced peripheral neuropathy: a serum metabolomics study in colorectal cancer patients.Frontiers in nutrition · 2026Article
- Polyphenol-enriched extraction fromRSC advances · 2025Article
- Design, Synthesis and Evaluation of Antioxidant and NSAID Derivatives with Antioxidant, Anti-Inflammatory and Plasma Lipid Lowering Effects.Molecules (Basel, Switzerland) · 2024Article
- Plasma Amino Acid Profiles and Clinical Outcome in Patients with Traumatic Brain Injury: A Study Protocol.Galen medical journal · 2024Article
- Astragaloside IV alleviates GDM via regulating gut microbiota and gut microbiota metabolomic.Frontiers in pharmacology · 2024Article
- Host metabolome predicts the severity and onset of acute toxicities induced by CAR T-cell therapy.Blood advances · 2023Article
- Effects of a Mealworm (Insects · 2022Article
- Effects of Traumatic Brain Injury on the Gut Microbiota Composition and Serum Amino Acid Profile in Rats.Cells · 2022Article
- Fish and Shellfish-Derived Anti-Inflammatory Protein Products: Properties and Mechanisms.Molecules (Basel, Switzerland) · 2021Review
- Neuroprotective Effect of Taurine against Cell Death, Glial Changes, and Neuronal Loss in the Cerebellum of Rats Exposed to Chronic-Recurrent Neuroinflammation Induced by LPS.Journal of immunology research · 2021Article
- Baicalin-Zinc Complex Alleviates Inflammatory Responses and Hormone Profiles by Microbiome in Deoxynivalenol Induced Piglets.Frontiers in nutrition · 2021Article
- Escalating morphine dosing in HIV-1 Tat transgenic mice with sustained Tat exposure reveals an allostatic shift in neuroinflammatory regulation accompanied by increased neuroprotective non-endocannabinoid lipid signaling molecules and amino acids.Journal of neuroinflammation · 2020Article
- Hippocampal transcriptome reveals novel targets of FASD pathogenesis.Brain and behavior · 2019Article
- Berberine ameliorates lipopolysaccharide-induced learning and memory deficit in the rat: insights into underlying molecular mechanisms.Metabolic brain disease · 2019Article
- The effect of dietary asparagine supplementation on energy metabolism in liver of weaning pigs when challenged with lipopolysaccharide.Asian-Australasian journal of animal sciences · 2018Article
- Metabolomic fingerprinting of milk fever cows: Pre- and postpartum metabolite alterations.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Although many studies show the toxic effects of proline, recently it has been reported some anti-inflammatory effect of this amino acid. Our principal objective was to investigate the effects of proline on the alterations caused by LPS (lipopolysaccharide) administration in the cerebral cortex and cerebellum of young Wistar rats. The animals were divided into four groups: control (0.85% saline); proline, (12.8 μmol of proline/g body weight from day 7 to 13; 14.6 μmol of proline/g body weight from day 14 to 17 and 16.4 μmol of proline/g body weight from day 18 to 21); LPS (1 mg/g body weight); LPS plus proline. The animals were killed at 22 days of age, 12 h after the last injection, by decapitation without anesthesia. The brain cortex and cerebellum were separated for chemical determinations. The effects of proline and LPS in the cerebral cortex and cerebellum on the expression of S100B and GFAP, oxidative stress parameters, enzymes of phosphoryl transfer network activity, and mitochondrial respiration chain complexes were investigated. Two-way ANOVA showed that the administration of proline did not alter the analyzed parameter in cerebral cortex and cerebellum. On the other hand, LPS administration caused a change in these parameters. Besides, the co-administration of proline and LPS showed the ability of Pro in preventing the effects of LPS. These results indicated that LPS induces inflammation, oxidative stress, and alters energy parameters in cerebral cortex and cerebellum of the rats. Moreover, co-administration of Pro was able to prevent these harmful effects of LPS.
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Registered trials
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