Evidence map›Paper›PMID 28585087›Full record

ArticleMolecular and cellular biochemistry2017

Corticosteroids and aldose reductase inhibitor Epalrestat modulates cardiac action potential via Kvβ1.1 (AKR6A8) subunit of voltage-gated potassium channel.

Jared Tur, Sachin L Badole, Feng Cheng, Aparoop Das, Rakesh C Kukreja, Srinivas M Tipparaju

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jared TurDepartment of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, 12901 Bruce B. Downs Blvd. MDC030, Tampa, FL, 33612, USA.
Sachin L BadoleDepartment of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, 12901 Bruce B. Downs Blvd. MDC030, Tampa, FL, 33612, USA.
Feng ChengDepartment of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, 12901 Bruce B. Downs Blvd. MDC030, Tampa, FL, 33612, USA.
Aparoop DasDepartment of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India.
Rakesh C KukrejaPauley Heart Center, Department of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Srinivas M TipparajuDepartment of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, 12901 Bruce B. Downs Blvd. MDC030, Tampa, FL, 33612, USA. stippara@health.usf.edu.
University of South Florida · USDibrugarh University · INVirginia Commonwealth University · US

Funding

Redox Regulation of Kv ChannelsR01HL102171 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI TIPPARAJU, SRINIVAS M. · 2011 to 2015
$1.6M
NHLBI NIH HHS R01 HL102171
6 · The paper itself

Abstract

We previously demonstrated the role of Kvβ1.1 subunit of voltage-activated potassium channel in heart for its sensory roles in detecting changes in NADH/NAD and modulation of ion channel. However, the pharmacological role for the association of Kvβ1 via its binding to ligands such as cortisone and its analogs remains unknown. Therefore, we investigated the significance of Kvβ1.1 binding to cortisone analogs and AR inhibitor epalrestat. In addition, the aldose reductase (AR) inhibitor epalrestat was identified as a pharmacological target and modulator of cardiac activity via binding to the Kvβ1 subunit. Using a combination of ex vivo cardiac electrophysiology and in silico binding, we identified that Kvβ1 subunit binds and interacts with epalrestat. To identify the specificity of the action potential changes, we studied the sensitivity of the action potential prolongation by probing the electrical changes in the presence of 4-aminopyridine and evaluated the specificity of pharmacological effects in the hearts from Kvβ1.1 knock out mouse. Our results show that pharmacological modulation of cardiac electrical activity by cortisone analogs and epalrestat is mediated by Kvβ1.1.

Indexed as

Action PotentialsAldehyde ReductaseAnimalsCortisoneEnzyme InhibitorsKv1.1 Potassium ChannelMiceMice, KnockoutMyocardiumRhodanineThiazolidinesAldehyde ReductaseCortisoneEnzyme InhibitorsepalrestatKv1.1 Potassium ChannelRhodanineThiazolidinesAldo–keto reductaseCortisoneHeartKvβ subunit

Identifiers

PMID28585087
PMCPMC6266872
OpenAlexW2622598573

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.