Observational studyIntensive care medicine2017
Peripherally inserted central catheters are associated with lower risk of bloodstream infection compared with central venous catheters in paediatric intensive care patients: a propensity-adjusted analysis.
Observational study in Intensive care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 81 citations in OpenAlex.
- Ultrasound-Guided Cannulation of the Great Saphenous Vein in Neonates: A Randomized Study.American journal of perinatology · 2023Trial
- [RCT of Reduction in Catheter-Related Complications by Using Intracavitary Electrocardiogram-Assisted Guidance in Neonatal PICC Placement].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2021Trial
- The impact of central line-specific dwell-times for neonatal central line associated bloodstream infections.Antimicrobial resistance and infection control · 2025Article
- Development and validation of a nomogram risk prediction model for PICC-related thrombosis in children with hematological malignancies.Clinical and experimental medicine · 2025Article
- Evaluating the Cost-Effectiveness of Chlorhexidine-Coated vs. Standard Peripheral Insertion Central Catheters in Patients with Hematologic Disease: A Health Economic Analysis.International journal of environmental research and public health · 2025Article
- Identifying high-risk central lines in critically ill children: A novel nurse-driven screening and mitigation intervention to reduce CLABSI.American journal of infection control · 2025Article
- PICC tip dislodgement causing massive pleural effusion and atelectasis with acute respiratory failure: a case report.BMC pediatrics · 2024Article
- Differences in the Dwell Time of Peripherally Inserted Central Catheters between Patients with Catheter Colonization and Those Developing Central Line-Associated Bloodstream Infection: A Single Centre Retrospective Cohort Study.Antibiotics (Basel, Switzerland) · 2024Article
- Nurse-to-patient ratios and readiness for hospital discharge: A moderated mediation model.Nursing open · 2024Article
- Risk factors for mechanical complications of peripherally inserted central catheters in children.Infection control and hospital epidemiology · 2023Article
- Peripherally inserted central catheters have a protective role and the effect of fluctuation curve feature in the risk of bloodstream infection compared with central venous catheters: a propensity-adjusted analysis.BMC infectious diseases · 2022Article
- Risk Factors for a Hospital-Acquired Carbapenem-ResistantInfection and drug resistance · 2022Article
- Delayed cardiac tamponade diagnosed by point-of-care ultrasound in a neonate after peripherally inserted central catheter placement: A case report.World journal of clinical cases · 2021Article
- Ultrasound-guided supraclavicular cannulation of the brachiocephalic vein may reduce central line-associated bloodstream infection in preterm infants.European journal of pediatrics · 2020Article
- Gastrointestinal stromal tumor metastasis at the site of a totally implantable venous access port insertion: A rare case report.World journal of clinical cases · 2020Article
- Peripherally inserted central venous catheter (PICC) in outpatient and inpatient oncological treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
- Peripherally inserted central catheters: a hidden emerging cause of infection outbreaks.New microbes and new infections · 2020Article
- Development and Implementation of a Bedside Peripherally Inserted Central Catheter Service in a PICU.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2019Observational
- Knowledge, attitude, and practice toward the daily management of PICC in critically ill cancer patients discharged from intensive care units.Cancer management and research · 2018Article
- Dislodgement Rates of Tunneled Femoral Peripherally Inserted Central Catheters in Pediatric Oncology Patients.Journal of infusion nursing : the official publication of the Infusion Nurses SocietyArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCentral line-associated bloodstream infection (CLABSI) is an important cause of complications in paediatric intensive care units (PICUs). Peripherally inserted central catheters (PICCs) could be an alternative to central venous catheters (CVCs) and the effect of PICCs compared with CVCs on CLABSI prevention is unknown in PICUs. Therefore, we aimed to evaluate whether PICCs were associated with a protective effect for CLABSI when compared to CVCs in critically ill children.
methodsWe have carried out a retrospective multicentre study in four PICUs in São Paulo, Brazil. We included patients aged 0-14 years, who needed a CVC or PICC during a PICU stay from January 2013 to December 2015. Our primary endpoint was CLABSI up to 30 days after catheter placement. We defined CLABSI based on the Center for Disease Control and Prevention's National Healthcare Safety Networks (NHSN) 2015 surveillance definitions. To account for potential confounders, we used propensity scores with inverse probability weighting.
resultsA total of 1660 devices (922 PICCs and 738 CVCs) in 1255 children were included. The overall CLABSI incidence was 2.28 (95% CI 1.70-3.07)/1000 catheter-days. After covariate adjustment using propensity scores, CVCs were associated with higher risk of CLABSI (adjHR 2.20, 95% CI 1.05-4.61; p = 0.037) compared with PICCs. In a sensitivity analysis, CVCs remained associated with higher risk of CLABSI (adjHR 2.18, 95% CI 1.02-4.64; p = 0.044) after adding place of insertion and use of parenteral nutrition to the model as a time-dependent variable.
conclusionsPICC should be an alternative to CVC in the paediatric intensive care setting for CLABSI prevention.
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