Observational studyJournal of neurology2017
Optical coherence tomography for the diagnosis and monitoring of idiopathic intracranial hypertension.
Observational study in Journal of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Exploring the utility of retinal optical coherence tomography as a biomarker for idiopathic intracranial hypertension: a systematic review.Journal of neurology · 2024Pooled it
- A Spectral-Domain-OCT-Guided One-Year Follow-Up of Newly Diagnosed Pediatric Idiopathic Intracranial Hypertension Patients.Diagnostics (Basel, Switzerland) · 2026Article
- Non invasive monitoring for spaceflight associated neuro ocular syndrome: responding to a need for In flight methodologies.NPJ microgravity · 2025Article
- Optical approaches for neurocritical care: Toward non-invasive recording of cerebral physiology in acute brain injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Macular exudate in idiopathic intracranial hypertension affects outer retina and visual acuity.BMJ open ophthalmology · 2024Article
- Optic Nerve Head and Retinal Changes in Idiopathic Intracranial Hypertension: Correlation with Short-Term Cerebrospinal Fluid Pressure Monitoring.Journal of clinical medicine · 2024Article
- Which OCT Measure of the Optic Nerve Head Improves Fastest? Towards Optimizing Early Detection of Resolving Papilledema in Children.Translational vision science & technology · 2024Article
- Interocular Symmetry and Intermachine Reproducibility of Optic Disc and Macular Parameters Measured by Two Different Models of Optical Coherence Tomography.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- The Vienna idiopathic intracranial hypertension database-An Austrian registry.Wiener klinische Wochenschrift · 2024Article
- Retinal microvascular and structural changes in intracranial hypertension patients correlate with intracranial pressure.CNS neuroscience & therapeutics · 2023Article
- Idiopathic intracranial hypertension: a step change in understanding the disease mechanisms.Nature reviews. Neurology · 2023Review
- Optic Nerve Head Changes Measured by Swept Source Optical Coherence Tomography and Angiography in Patients with Intracranial Hypertension.Ophthalmology and therapy · 2023Article
- Risk factors associated with progression from papilloedema to optic atrophy: results from a cohort of 113 patients.BMJ open ophthalmology · 2023Article
- The Importance of Optical Coherence Tomography in the Diagnosis of Atypical or Subclinical Optic Neuritis: A Case Series Study.Journal of clinical medicine · 2023Article
- Diagnosis of Optic Disc Oedema: Fundus Features, Ocular Imaging Findings, and Artificial Intelligence.Neuro-ophthalmology (Aeolus Press) · 2023Review
- Article
- A machine learning approach in the non-invasive prediction of intracranial pressure using Modified Photoplethysmography.PloS one · 2022Article
- An update on idiopathic intracranial hypertension in adults: a look at pathophysiology, diagnostic approach and management.Journal of neurology · 2021Review
- Artificial intelligence extension of the OSCAR-IB criteria.Annals of clinical and translational neurology · 2021Review
- Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as inflammation markers in patients with papilledema due to idiopathic intracranial hypertension.Indian journal of ophthalmology · 2021Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objectives of the study were to investigate the value of optical coherence tomography in detecting papilledema in patients with idiopathic intracranial hypertension (IIH), a disease which is difficult to monitor and which can lead to permanent visual deficits; to analyze retinal changes over time. In this non-interventional case-control study, spectral-domain optical coherence tomography (SD-OCT) was used to analyze the retinal and optic nerve head (ONH) morphology of 21 patients with IIH and 27 age- and sex-matched healthy controls over time. We analyzed the ONH volume using a custom-made algorithm and employed semi-automated segmentation of macular volume scans to assess the macular retinal nerve fiber layer (RNFL) and ganglion cell layer and inner plexiform layer complex as well as the total macular volume. In IIH patients, the ONH volume was increased and correlated with cerebrospinal fluid (CSF) pressure. The ONH volume decreased after the initiation of treatment with acetazolamide. The macular RNFL volume decreased by 5% in 3.5 months, and a stepwise multivariate regression analysis identified CSF pressure as the main influence on macular RNFL volume at diagnosis. The only factor predicting macular RNFL volume loss over time was ONH volume. SD-OCT can non-invasively monitor changes in retinal and ONH morphology in patients with IIH. Increased ONH volume leads to retinal atrophy in the form of macular RNFL volume loss, presumably due to mechanic jamming of the optic nerve at the disc and subsequent axonal loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.