ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2017
Increases in Intrinsic Thalamocortical Connectivity and Overall Cognition Following Cognitive Remediation in Chronic Schizophrenia.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Cognitive training for schizophrenia: Do race and ethnicity matter?Schizophrenia research · 2024Trial
- Increased global cognition correlates with increased thalamo-temporal connectivity in response to targeted cognitive training for recent onset schizophrenia.Schizophrenia research · 2020Trial
- Efference copy/corollary discharge function and targeted cognitive training in patients with schizophrenia.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2019Trial
- Effective connectivity changes in LSD-induced altered states of consciousness in humans.Proceedings of the National Academy of Sciences of the United States of America · 2019Trial
- Response to Targeted Cognitive Training Correlates with Change in Thalamic Volume in a Randomized Trial for Early Schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Editorial: From causal circuit mapping to clinical translation: Prefronto-thalamic hypoconnectivity in schizophrenia.PCN reports : psychiatry and clinical neurosciences · 2026Article
- Functional Connectivity Biomarkers in Schizophrenia.Advances in neurobiology · 2024Review
- The psychosis human connectome project: Design and rationale for studies of visual neurophysiology.NeuroImage · 2023Article
- Psychosis spectrum illnesses as disorders of prefrontal critical period plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Thalamic Connectivity System Across Psychiatric Disorders: Current Status and Clinical Implications.Biological psychiatry global open science · 2022Review
- Frontotemporal thalamic connectivity in schizophrenia and schizotypal personality disorder.Psychiatry research. Neuroimaging · 2022Article
- Returning to basic principles to develop more effective treatments for central nervous system disorders.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Imbalance Between Prefronto-Thalamic and Sensorimotor-Thalamic Circuitries Associated with Working Memory Deficit in Schizophrenia.Schizophrenia bulletin · 2022Article
- Multivariate pattern analysis of brain structure predicts functional outcome after auditory-based cognitive training interventions.NPJ schizophrenia · 2021Article
- Response to targeted cognitive training may be neuroprotective in patients with early schizophrenia.Psychiatry research. Neuroimaging · 2021Article
- Differential Roles of Mediodorsal Nucleus of the Thalamus and Prefrontal Cortex in Decision-Making and State Representation in a Cognitive Control Task Measuring Deficits in Schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Schizophrenia Exhibits Bi-directional Brain-Wide Alterations in Cortico-Striato-Cerebellar Circuits.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Disrupted modulation of thalamus activation and thalamocortical connectivity during dual task performance in schizophrenia.Schizophrenia research · 2019Article
- Prefrontal-Thalamic Anatomical Connectivity and Executive Cognitive Function in Schizophrenia.Biological psychiatry · 2018Article
- White matter microstructure predicts cognitive training-induced improvements in attention and executive functioning in schizophrenia.Schizophrenia research · 2018Article
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3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThalamic projections to the prefrontal cortex (PFC) are critical for cognition, and disruptions in these circuits are thought to underlie the pathophysiology of schizophrenia. Cognitive remediation (REM) is a behavioral intervention that holds promise for improving cognition and functioning in schizophrenia, however the extent to which it affects thalamo-prefrontal connections has not been researched. This study sought to determine whether patients with schizophrenia who undergo a placebo-controlled trial of REM show increased functional connectivity between the thalamus and PFC, and whether these changes correspond to improvements in cognition.
methodsTwenty-six patients with chronic schizophrenia were randomized to either 48 hours (over 16 weeks) of a drill-and-practice working memory-focused REM or an active placebo condition. All participants underwent cognitive assessment (MATRICS Consensus Cognitive Battery), as well as both resting and task-based fMRI before and after their respective intervention. All clinicians, technicians, and raters were blind to participant condition.
resultsWe observed changes in resting-state connectivity in the PFC for the REM group but not the placebo group. Increased intrinsic connectivity between the thalamus and right middle frontal gyrus correlated with improvements in overall cognition. Additionally, lower baseline cognition correlated with greater increases in connectivity between the thalamus and PFC. Similar findings were observed when patients were scanned during a working memory task.
conclusionsThese results suggest that increases in thalamo-prefrontal circuitry correspond with training-related improvements of the cognitive deficits associated with schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.