Evidence map›Paper›PMID 28584857›Full record

ArticleOpen forum infectious diseases2017

Evolving Failures in the Delivery of Human Immunodeficiency Virus Care: Lessons From a Ugandan Meningitis Cohort 2006-2016.

Andrew G Flynn, David B Meya, Katherine Huppler Hullsiek, Joshua Rhein, Darlisha A Williams, Abdu Musubire, Bozena M Morawski, Kabanda Taseera, Alisat Sadiq, Liberica Ndyatunga and 5 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Cryptococcal meningitis.Nature reviews. Disease primers · 2023
    Review
  5. Article
  6. Article
  7. Cryptococcal Antigenemia in Human Immunodeficiency Virus Antiretroviral Therapy-Experienced Ugandans With Virologic Failure.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Andrew G FlynnInfectious Diseases Institute, Mulago Hospital Complex, Makerere University, Kampala, Uganda.
David B MeyaInfectious Diseases Institute, Mulago Hospital Complex, Makerere University, Kampala, Uganda.
Katherine Huppler HullsiekDivision of Biostatistics, University of Minnesota School of Public Health, Minneapolis.
Joshua RheinInfectious Diseases Institute, Mulago Hospital Complex, Makerere University, Kampala, Uganda.
Darlisha A WilliamsInfectious Diseases Institute, Mulago Hospital Complex, Makerere University, Kampala, Uganda.
Abdu MusubireInfectious Diseases Institute, Mulago Hospital Complex, Makerere University, Kampala, Uganda.
Bozena M MorawskiDivision of Biostatistics, University of Minnesota School of Public Health, Minneapolis.
Kabanda TaseeraMbarara University of Science and Technology, Mbarara, Uganda.
Alisat SadiqInfectious Diseases Institute, Mulago Hospital Complex, Makerere University, Kampala, Uganda.
Liberica NdyatungaMbarara University of Science and Technology, Mbarara, Uganda.
Mollie RoedigerDivision of Biostatistics, University of Minnesota School of Public Health, Minneapolis.
Radha RajasinghamDepartment of Medicine, University of Minnesota Medical School, Minneapolis.
Paul R BohjanenDepartment of Medicine, University of Minnesota Medical School, Minneapolis.
Conrad MuzooraMbarara University of Science and Technology, Mbarara, Uganda.
David R BoulwareDepartment of Medicine, University of Minnesota Medical School, Minneapolis.
Infectious Diseases Institute · UGMbarara University of Science and Technology · UGUniversity of Minnesota · USUniversity of Minnesota Medical Center · USMulago Hospital · UG

Funding

Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related MeningitisR01NS086312 · NINDS · UNIVERSITY OF MINNESOTA · PI David R Boulware, David Bisagaya Meya · 2013 to 2026
$8.3M
Trial for the Optimal Timing of HIV Therapy after Cryptococcal MeningitisU01AI089244 · NIAID · UNIVERSITY OF MINNESOTA · PI BOULWARE, DAVID R · 2010 to 2014
$7.6M
Infectious Disease Training in Clinical InvestigationT32AI055433 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI David R Boulware · 2003 to 2026
$6.1M
Northern/Pacific Universities Global Health Research Training ConsortiumR25TW009345 · FIC · UNIVERSITY OF WASHINGTON · PI KOLARS, JOSEPH C., NERURKAR, VIVEK RAMCHANDRA · 2012 to 2016
$5.9M
Outcomes of Cryptococcal Meningitis in UgandaK24AI096925 · NIAID · UNIVERSITY OF MINNESOTA · PI BOHJANEN, PAUL R · 2011 to 2015
$1.0M
Improving Outcomes of HIV-Associated Cryptococcosis in Resource-Limited SettingsK01TW010268 · FIC · UNIVERSITY OF MINNESOTA · PI RHEIN, JOSHUA R · 2016 to 2020
$703k
Epidemiology, Immunopathogenesis, and Outcomes of Non-traumatic Spinal Cord Injury in UgandaK43TW010718 · FIC · INFECTIOUS DISEASES INSTITUTE · PI MUSUBIRE, ABDU KISEKKA · 2017 to 2021
$514k
FIC NIH HHS K01 TW010268FIC NIH HHS K43 TW010718FIC NIH HHS R25 TW009345Medical Research Council MR/M007413/1NIAID NIH HHS K24 AI096925NIAID NIH HHS T32 AI055433NIAID NIH HHS U01 AI089244NINDS NIH HHS R01 NS086312
6 · The paper itself

Abstract

backgroundBecause of investments in human immunodeficiency virus (HIV) care in sub-Saharan Africa, the number of people aware of their status and receiving antiretroviral therapy (ART) has increased; however, HIV/acquired immune deficiency syndrome (AIDS) mortality still remains high.

methodsWe performed retrospective analysis of 3 sequential prospective cohorts of HIV-infected Ugandan adults presenting with AIDS and meningitis from 2006 to 2009, 2010 to 2012, and 2013 to 2016. Participants were categorized as follows: (1) unknown HIV status; (2) known HIV

resultsWe screened 1353 persons with suspected meningitis.

conclusionsAlthough improved HIV screening and ART access remain much-needed interventions in resource-limited settings, greater investment in viral suppression and opportunistic infection care among the growing HIV-infected population receiving ART is essential to reducing ongoing AIDS mortality.

Indexed as

antiretroviral therapycryptococcal meningitisHIV/AIDSHIV care continuumsub-Saharan Africa.

Identifiers

PMID28584857
PMCPMC5451663
OpenAlexW2605712021

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.