ArticleCritical care research and practice2017
Melatonin Secretion Pattern in Critically Ill Patients: A Pilot Descriptive Study.
Article in Critical care research and practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- A Systematic Review of Sleep Measurement in Critically Ill Patients.Frontiers in neurology · 2020Pooled it
- Are circadian rhythms in disarray in patients with chronic critical illness?Sleep medicine: X · 2024Article
- Sleep and circadian rhythm disturbances in intensive care unit (ICU)-acquired delirium: a case-control study.The Journal of international medical research · 2021Article
- Factors Disrupting Melatonin Secretion Rhythms During Critical Illness.Critical care medicine · 2020Observational
- Abnormal Sleep, Circadian Rhythm Disruption, and Delirium in the ICU: Are They Related?Frontiers in neurology · 2020Review
- Sleep quality in survivors of critical illness.Sleep & breathing = Schlaf & Atmung · 2019Article
- Sleep quality and circadian rhythm disruption in the intensive care unit: a review.Nature and science of sleep · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Critically ill patients have abnormal circadian and sleep homeostasis. This may be associated with higher morbidity and mortality. The aims of this pilot study were (1) to describe melatonin secretion in conscious critically ill mechanically ventilated patients and (2) to describe whether melatonin secretion and sleep patterns differed in these patients with and without remifentanil infusion. Eight patients were included. Blood-melatonin was taken every 4th hour, and polysomnography was carried out continually during a 48-hour period. American Academy of Sleep Medicine criteria were used for sleep scoring if sleep patterns were identified; otherwise, Watson's classification was applied. As remifentanil was periodically administered during the study, its effect on melatonin and sleep was assessed. Melatonin secretion in these patients followed a phase-delayed diurnal curve. We did not observe any effect of remifentanil on melatonin secretion. We found that the risk of atypical sleep compared to normal sleep was significantly lower (
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.