ArticleBiomedical reports2017
Evaluation of tumor necrosis factor (TNF)-α mRNA expression level and the rs1799964 polymorphism of the TNF-α gene in peripheral mononuclear cells of patients with inflammatory bowel diseases.
Article in Biomedical reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Pooled it
- Review of Genetic Variation as a Predictive Biomarker for Chronic Graft-Versus-Host-Disease After Allogeneic Stem Cell Transplantation.Frontiers in immunology · 2020Pooled it
- A novel predictive approach for GVHD after allogeneic SCT based on clinical variables and cytokine gene polymorphisms.Blood advances · 2018Trial
- Associations between TNF gene promoter variants (rs361525, rs1800629, rs1799964, rs1799724) and the clinical course of idiopathic inflammatory myopathies.Scientific reports · 2025Article
- Association Between Genetic Variants inDiagnostics (Basel, Switzerland) · 2025Article
- Thermo-responsive methylcellulose/hyaluronic acid-mesalamine hydrogel in targeted drug delivery for ulcerative colitis.RSC advances · 2025Article
- Evaluation of the association between TNF-α-1031 T/C polymorphism with oral lichen planus disease.BMC oral health · 2024Article
- Genetic polymorphisms as predictive biomarkers of adverse events during preoperative chemotherapy in esophageal cancer.Cancer chemotherapy and pharmacology · 2024Article
- High expression of HOXC6 predicts a poor prognosis and induces proliferation and inflammation in multiple myeloma cells.Genes & genomics · 2023Article
- Association of interleukin-8 polymorphism (+ 781 C/T) with the risk of oral Lichen Planus disease.BMC oral health · 2023Article
- Evaluating Associations between Average Pain Intensity and Genetic Variation in People with Sickle Cell Disease: An Exploratory Study.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2023Article
- TNF-α-1031T/C gene polymorphism as a predictor of malnutrition in patients with gastric cancer.Frontiers in nutrition · 2023Article
- Toll-Like Receptor 7 a Novel Non-Invasive Inflammatory Genetic Sensor for Ulcerative Colitis Remission Monitoring.Advanced biomedical research · 2023Article
- TNFα rs1799964 TT genotype may be a susceptibility factor for vertical transmission of Toxoplasma gondii and clinical signs in newborns from pregnant women with acute toxoplasmosis.Molecular biology reports · 2022Article
- Genetic Association between TNFA Polymorphisms (rs1799964 and rs361525) and Susceptibility to Cancer in Systemic Sclerosis.Life (Basel, Switzerland) · 2022Article
- Targeted screening of genetic associations with COVID-19 susceptibility and severity.Frontiers in genetics · 2022Article
- Selective serotonin reuptake inhibitors and inflammatory bowel disease; Beneficial or malpractice.Frontiers in immunology · 2022Review
- Association of TNF-α -308G > A polymorphism with susceptibility to tendinopathy in athletes: a case-control study.BMC sports science, medicine & rehabilitation · 2021Article
- Immunosuppressive effect of cyclophosphamide in Nile tilapia (Oreochromis niloticus).Environmental science and pollution research international · 2021Article
- Association between Genetic Variants inViruses · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crohn's disease (CD) and ulcerative colitis (UC) are types of chronic inflammatory bowel disease (IBD) of which the actual causes remain unknown. Emerging data indicate that alterations in cytokine synthesis may be involved in IBD pathogenesis. The aim of the present study was to determine whether the tumor necrosis factor (TNF)-α mRNA expression level and rs1799964 polymorphism are the genetic susceptibility component of IBD development. The TNF-α mRNA expression level of peripheral blood mononuclear cells (PBMCs) was measured using comparative reverse-transcription quantitative polymerase chain reaction (PCR). Genomic DNA from 201 individuals (CD: n=15; UC: n=86; control subjects: n=100) was analyzed for the presence of the
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.