Evidence map›Paper›PMID 28584625›Full record

ArticleClinical kidney journal2017

Digital pathology imaging as a novel platform for standardization and globalization of quantitative nephropathology.

Laura Barisoni, Charlotte Gimpel, Renate Kain, Arvydas Laurinavicius, Gloria Bueno, Caihong Zeng, Zhihong Liu, Franz Schaefer, Matthias Kretzler, Lawrence B Holzman and 1 more

Open access · goldAbstract read
In one paragraph

Article in Clinical kidney journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Quantification of Glomerular Structural Lesions: Associations With Clinical Outcomes and Transcriptomic Profiles in Nephrotic Syndrome.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022
    Observational
  7. Article
  8. Article
  9. Article
  10. AI applications in renal pathology.Kidney international · 2021
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Observational
  18. Article
  19. Artificial intelligence driven next-generation renal histomorphometry.Current opinion in nephrology and hypertension · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 11 institutions in 6 countries.

Laura BarisoniDepartment of Pathology, University of Miami, Miller School of Medicine, Miami, FL, USA.
Charlotte GimpelDepartment of General Pediatrics, Adolescent Medicine and Neonatology, Center for Pediatrics, Medical Center - University of Freiburg, Germany.
Renate KainClinical Department of Pathology, Medical University of Vienna, Vienna, Austria.
Arvydas LaurinaviciusFaculty of Medicine and National Center of Pathology, Vilnius University, Vilnius, Lithuania.
Gloria BuenoVISILAB - E.T.S.I.I., University of Castilla-La Mancha, Ciudad Real, Spain.
Caihong ZengNational Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
Zhihong LiuNational Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
Franz SchaeferUniversity Children Hospital, Pediatric Nephrology, Heidelberg, Germany.
Matthias KretzlerDepartment of Internal Medicine and Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Lawrence B HolzmanRenal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Stephen M HewittLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Center for Cancer Research · USMedical University of Vienna · ATNanjing General Hospital of Nanjing Military Command · CNNanjing University · CNUniversity Hospital Heidelberg · DEUniversity of Castilla-La Mancha · ESUniversity of Freiburg · DEUniversity of Miami · USUniversity of Michigan–Ann Arbor · USUniversity of Pennsylvania · USVilnius University · LT

Funding

Training Program in Clinical & Translationa Research in Human Glomerular DiseaseU54DK083912 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KRETZLER, MATTHIAS · 2009 to 2023
$20.3M
Computational Pathology of Proteinuric DiseasesR01DK118431 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BARISONI, LAURA MARIACHIARA, HODGIN, JEFFREY BENTON · 2018 to 2025
$3.6M
NIDDK NIH HHS U54 DK083912
6 · The paper itself

Abstract

The introduction of digital pathology to nephrology provides a platform for the development of new methodologies and protocols for visual, morphometric and computer-aided assessment of renal biopsies. Application of digital imaging to pathology made substantial progress over the past decade; it is now in use for education, clinical trials and translational research. Digital pathology evolved as a valuable tool to generate comprehensive structural information in digital form, a key prerequisite for achieving precision pathology for computational biology. The application of this new technology on an international scale is driving novel methods for collaborations, providing unique opportunities but also challenges. Standardization of methods needs to be rigorously evaluated and applied at each step, from specimen processing to scanning, uploading into digital repositories, morphologic, morphometric and computer-aided assessment, data collection and analysis. In this review, we discuss the status and opportunities created by the application of digital imaging to precision nephropathology, and present a vision for the near future.

Indexed as

glomerulosclerosiskidney biopsyminimal change diseasenephrotic syndromeproteinuria

Identifiers

PMID28584625
PMCPMC5455257
OpenAlexW2590235945

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.