Evidence map›Paper›PMID 28584570›Full record

ReviewOncology reviews2017

Bone Metastases: An Overview.

Filipa Macedo, Katia Ladeira, Filipa Pinho, Nadine Saraiva, Nuno Bonito, Luisa Pinto, Francisco Goncalves

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Oncology reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04808531 (NanaBis™ an Oro-buccal Administered Equimolar d9-THC & CBD Formulation as Monotherapy for Management of Opioid Requiring Bone Pain Due to Metastatic Cancer), which is not on this map. Cited by 488 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
488citing papers in PubMed, 7 pooled it
26.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04808531 phase3unknown statusnot on this mapstarted 2023, after this paper: background citation

NanaBis™ an Oro-buccal Administered Equimolar d9-THC & CBD Formulation as Monotherapy for Management of Opioid Requiring Bone Pain Due to Metastatic Cancer: Phase 3 Multi Centre Blinded Randomized Withdrawal Active & Placebo Controlled Trial

TypeinterventionalSponsorMedlab ClinicalRan2023 to 2024Enrolled360ConditionsCancer Related PainArmsNanaBis™, Oxycodone CR, Placebo Spray, Placebo Tablet, Oxycodone IR
3 · Its place in the literature

Who cites it

488 citing papers in PubMed, 7 syntheses or guidelines pooled it, 758 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  6. Pooled it
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  8. Trial
  9. Article
  10. Article
  11. Review
  12. Article
  13. Observational
  14. Article
  15. Detecting Distant Metastases in Prostate Cancer Using Whole-body MR Imaging Together with DWIBS (Diffusion-weighted Imaging with Background Body Signal Suppression).Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
    Review
  16. Article
  17. Prognostic parameters for local control and survival after radiotherapy of stabilized bone metastases.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Article
  18. Article
  19. Review
  20. Article

428 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Filipa MacedoMedical Oncology Department, Portuguese Oncology Institute, Coimbra, Portugal.
Katia LadeiraInternal Medicine Department, Braga Hospital, Braga, Portugal.
Filipa PinhoInternal Medicine Department, Braga Hospital, Braga, Portugal.
Nadine SaraivaMedical Oncology Department, Portuguese Oncology Institute, Coimbra, Portugal.
Nuno BonitoMedical Oncology Department, Portuguese Oncology Institute, Coimbra, Portugal.
Luisa PintoInternal Medicine Department, Braga Hospital, Braga, Portugal.
Francisco GoncalvesInternal Medicine Department, Braga Hospital, Braga, Portugal.
Hospital Braga · PTInstituto Português de Oncologia Francisco Gentil · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone is a frequent site of metastases and typically indicates a short-term prognosis in cancer patients. Once cancer has spread to the bones it can rarely be cured, but often it can still be treated to slow its growth. The majority of skeletal metastases are due to breast and prostate cancer. Bone metastasis is actually much more common than primary bone cancers, especially in adults. The diagnosis is based on signs, symptoms and imaging. New classes of drugs and new interventions are given a better quality of life to these patients and improved the expectancy of life. It is necessary a multidisciplinary approach to treat patients with bone metastasis. In this paper we review the types, clinical approach and treatment of bone metastases.

Indexed as

bisphosphonatesBone metastasisdenosumabfracturesradiotherapy

Identifiers

PMID28584570
PMCPMC5444408
OpenAlexW2612478849

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.