ArticleIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine2017
The Effect of High-dose Parenteral Sodium Selenite in Critically Ill Patients following Sepsis: A Clinical and Mechanistic Study.
Article in Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 4 of them syntheses that pooled it.
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The trial behind it
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Who cites it
12 citing papers in PubMed, 4 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- The effect of selenium therapy in critically ill patients: an umbrella review of systematic reviews and meta-analysis of randomized controlled trials.European journal of medical research · 2023Pooled it
- The Impact of Selenium Supplementation on Trauma Patients-Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- The clinical outcomes of selenium supplementation on critically ill patients: A meta-analysis of randomized controlled trials.Medicine · 2019Pooled it
- A meta-analysis of randomized controlled trials: Efficacy of selenium treatment for sepsis.Medicine · 2019Pooled it
- The effects of antioxidant supplementation on short-term mortality in sepsis patients.Heliyon · 2024Article
- Inhibition and Removal of Mature Mixed-Bacteria Biofilms on Voice Prostheses by Sodium Selenite.Infection and drug resistance · 2022Article
- The effects of selenium supplementation on inflammatory markers in critically ill patients.SN applied sciences · 2022Review
- The impact of selenium administration on severe sepsis or septic shock: a meta-analysis of randomized controlled trials.African health sciences · 2021Article
- Selenium Deficiency in Lymphedema and Lipedema-A Retrospective Cross-Sectional Study from a Specialized Clinic.Nutrients · 2020Article
- Selenoprotein P as Biomarker of Selenium Status in Clinical Trials with Therapeutic Dosages of Selenite.Nutrients · 2020Article
- Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter?Intensive care medicine experimental · 2019Review
- Association of Initial Low Serum Selenium Level with Infectious Complications and 30-Day Mortality in Multiple Trauma Patients.Nutrients · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSevere sepsis and septic shock is characterized by inflammation and oxidative stress. Selenium levels have been reported to be low due to loss or increased requirements during severe sepsis and septic shock. We investigated the effect of high-dose parenteral selenium administration in septic patients.
methodsA prospective, randomized control clinical trial was performed in septic patients. After randomization, patients in selenium group received high-dose parenteral sodium selenite (2 mg intravenous [IV] bolus followed by 1.5 mg IV continuous infusion daily for 14 days) plus standard therapy and the control group received standard therapy. The primary endpoint was mortality at 28 days. Changes in the mean levels of high mobility group box-1 (HMGB-1) protein and superoxide dismutase (SOD), duration of vasopressor therapy, incidence of acute renal failure, and 60 days' mortality were secondary endpoints.
resultsFifty-four patients were randomized into selenium group (
conclusionIn early administration within the first 6 h of sepsis diagnosis, our study demonstrated that high-dose parenteral selenium administration had no significant effect either on 28-day mortality or the mean levels of HMGB-1 and SOD (Trial Registration: IRCT201212082887N4 at WHO Clinical Trial Registry, August 29, 2014).
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