Evidence map›Paper›PMID 28584395›Full record

ArticleJournal of clinical biochemistry and nutrition2017

Effect of amifostine, a radiation-protecting drug, on oxygen concentration in tissue measured by EPR oximetry and imaging.

Megumi Ueno, Shingo Matsumoto, Atsuko Matsumoto, Sushma Manda, Ikuo Nakanishi, Ken-Ichiro Matsumoto, James B Mitchell, Murali C Krishna, Kazunori Anzai

Open access · diamondAbstract read
In one paragraph

Article in Journal of clinical biochemistry and nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Accelerated EPR imaging using deep learning denoising.Magnetic resonance in medicine · 2025
    Article
  3. Article
  4. Article
  5. Biological Protection in Deep Space Missions.Journal of biomedical physics & engineering · 2021
    Review
  6. Article
  7. Article
  8. Medicinal Thiols: Current Status and New Perspectives.Mini reviews in medicinal chemistry · 2020
    Review
  9. Article
  10. Article
  11. Protective Effects of Polydatin on Reproductive Injury Induced by Ionizing Radiation.Dose-response : a publication of International Hormesis Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Megumi UenoRadio-Redox-Response Research Team, Advanced Particle Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, Japan.
Shingo MatsumotoRadiation Biology Branch, Center for Cancer Research, National Cancer Institute, Building 10, NIH, Bethesda, MD 20892-1002, USA.
Atsuko MatsumotoRadio-Redox-Response Research Team, Advanced Particle Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, Japan.
Sushma MandaRadio-Redox-Response Research Team, Advanced Particle Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, Japan.
Ikuo NakanishiRadio-Redox-Response Research Team, Advanced Particle Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, Japan.
Ken-Ichiro MatsumotoRadio-Redox-Response Research Team, Advanced Particle Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, Japan.
James B MitchellRadiation Biology Branch, Center for Cancer Research, National Cancer Institute, Building 10, NIH, Bethesda, MD 20892-1002, USA.
Murali C KrishnaRadiation Biology Branch, Center for Cancer Research, National Cancer Institute, Building 10, NIH, Bethesda, MD 20892-1002, USA.
Kazunori AnzaiRadio-Redox-Response Research Team, Advanced Particle Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, Japan.
Institute of Particle Physics · CACenter for Cancer Research · USCancer Institute (WIA) · INNihon Pharmaceutical University · JP

Funding

Protection against Radiation-Induced CarcinogenesisZIABC010946 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MITCHELL, JAMES · 2009 to 2025
$12.2M
6 · The paper itself

Abstract

Effect of amifostine, a radiation-protecting drug, on muscle tissue partial pressure of oxygen was investigated by electron paramagnetic resonance spectroscopy and imaging. When amifostine was administered intraperitoneally or intravenously to mice, the linewidth of the electron paramagnetic resonance spectra of the lithium octa-

Indexed as

amifostineEPR imagingEPR oximetryhypoxiaradioprotector

Identifiers

PMID28584395
PMCPMC5453015
OpenAlexW2601407737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.