Evidence map›Paper›PMID 28584299›Full record

ArticleInternational journal of obesity (2005)2017

Dissociation of body mass index, excess weight loss and body fat percentage trajectories after 3 years of gastric bypass: relationship with metabolic outcomes.

J Gómez-Ambrosi, P Andrada, V Valentí, F Rotellar, C Silva, V Catalán, A Rodríguez, B Ramírez, R Moncada, J Escalada and 2 more

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Article in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Trial
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  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Relevance of body composition in phenotyping the obesities.Reviews in endocrine & metabolic disorders · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Why does obesity cause diabetes?Cell metabolism · 2022
    Review
  18. Impact of Bariatric Surgery on Adipose Tissue Biology.Journal of clinical medicine · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

J Gómez-AmbrosiMetabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain.
P AndradaDepartment of Endocrinology and Nutrition, Clínica Universidad de Navarra, Pamplona, Spain.
V ValentíCentro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Pamplona, Spain.
F RotellarDepartment of Surgery, Clínica Universidad de Navarra, Pamplona, Spain.
C SilvaCentro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Pamplona, Spain.
V CatalánMetabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain.
A RodríguezMetabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain.
B RamírezMetabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain.
R MoncadaCentro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Pamplona, Spain.
J EscaladaCentro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Pamplona, Spain.
J SalvadorCentro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Pamplona, Spain.
G FrühbeckMetabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesBody weight, body mass index (BMI) and excess weight loss (EWL) are the most frequently used measures to analyse bariatric surgery outcomes. However, these measurements do not provide accurate information on body composition (BC) with body fat (BF), importantly determining the levels of cardiometabolic risk factors. Our aim was to analyse the evolution of BC after Roux-en-Y Gastric Bypass (RYGB) and its influence on the changes of cardiometabolic risk factors in comparison to BMI and EWL. SUBJECTS/

methodsA group of 81 obese Caucasian patients (19 males/62 females) aged 44.9±1.3 years undergoing RYGB between January 2006 and December 2011 was prospectively followed up for a period of 3 years. BC was determined by air-displacement plethysmography. Visceral adiposity, physical activity and cardiometabolic risk factors were measured.

resultsBF was markedly (P<0.001) reduced after the first year, increasing progressively during the second and third years after RYGB, following a different trajectory than body weight, BMI and EWL that decreased up to the second year post surgery. Markers of glucose homeostasis decreased during the first month and continued to decrease during the first year (P<0.05), remaining stabilised or slightly increased between the second and third years following RYGB. However, markers of lipid metabolism decreased (P<0.05) markedly during the first 12 months, increasing thereafter in parallel to the changes observed in BC, with the exception of high-density lipoprotein-cholesterol, which increased progressively throughout the whole period analysed.

conclusionsThe adverse switch in the changes in BC between the first and the second years after RYGB may underlie the changes observed in cardiometabolic risk factors. Tracking of adiposity during the follow-up of bariatric/metabolic surgery yields clinically relevant information to better identify patients in need of increased lifestyle advice or treatment intensification.

Indexed as

Gastric BypassAdipose TissueAdultBody Mass IndexCardiovascular DiseasesFemaleFollow-Up StudiesHumansLipid MetabolismLipoproteins, HDLMaleMetabolic SyndromeMiddle AgedObesity, AbdominalObesity, MorbidPlethysmographyLipoproteins, HDL

Identifiers

PMID28584299

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.