ArticleScientific reports2017
Persistent LHPA Activation in German Individuals Raised in an Overprotective Parental Behavior.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Associations among hair cortisol-to-DHEA ratio, psychological capital, harsh parenting, and internalizing problems in adolescence.Frontiers in psychology · 2026Article
- Article
- Mechanisms of Epigenetic Inheritance in Post-Traumatic Stress Disorder.Life (Basel, Switzerland) · 2024Review
- Perceived parenting styles and incidence of major depressive disorder: results from a 6985 freshmen cohort study.BMC psychiatry · 2023Article
- Longitudinal Trajectories of Hair Cortisol: Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Early Childhood.Frontiers in pediatrics · 2021Article
- The Stress of Caring-Resilience and HPA-Axis Activity in Hair Samples of Youth Residential Caregivers.Frontiers in psychiatry · 2020Article
- Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2018Article
- Stress hormone response to the DEX-CRH test and its relation to psychotherapy outcome in panic disorder patients with and without agoraphobia.Translational psychiatry · 2018Article
- Countering posttraumatic LHPA activation in refugee mothers and their infants.Molecular psychiatry · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parental upbringing may affect their offspring's mental state across the entire lifespan. Overprotective parental child-rearing style may increase the disease burden in the offspring. Furthermore, this child-rearing style may also play a pathogenetic role by transmitting trauma- and stressor-related disorders (TSRD) across generations. Studies with animals have demonstrated that the mother's immediate and expansive protection of the newborn decreases the limbic-hypothalamic-pituitary-adrenal (LHPA) axis activity in the offspring. However, few studies have investigated how stress impact humans raised in an overprotective manner. In a cross-sectional study with 40 healthy students recalling their overprotective upbringing, we show an increase in the dehydroepiandrostendione (DHEA) concentration and a reduction in the cortisol/DHEA-ratio in hair. Additionally, this child rearing style was associated with heightened indications of mental burden, depressiveness, and sense of coherence. Our results provide insight into the roots and consequences of psychological trauma across several generations. Further investigations focusing particularly on multigenerational transmission in extremely burdened families will augment our results.
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