ArticleScientific reports2017
Changes in retinal metabolic profiles associated with form deprivation myopia development in guinea pigs.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Metabolomics facilitates the discovery of metabolic profiles and pathways for myopia: A systematic review.Eye (London, England) · 2023Pooled it
- Mechanisms Underlying Myopia Progression from Visual Signaling to Metabolic Remodeling in Retina.JMA journal · 2025Review
- Critical role of lipid metabolism in axial myopia development.International journal of ophthalmology · 2025Review
- Metabolic Characteristics of Sclera in Lens-Induced Myopic Guinea Pigs.Investigative ophthalmology & visual science · 2024Article
- Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.iScience · 2024Article
- Article
- Widespread Involvement of Acetylation in the Retinal Metabolism of Form-Deprivation Myopia in Guinea Pigs.ACS omega · 2023Article
- The Role of Retinal Dysfunction in Myopia Development.Cellular and molecular neurobiology · 2023Review
- Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia.Neuroscience bulletin · 2022Article
- Long-Wavelength-Filtered Light Transiently Inhibits Negative Lens-Induced Axial Eye Growth in the Chick Myopia Model.Translational vision science & technology · 2021Article
- Electroretinography and Gene Expression Measures Implicate Phototransduction and Metabolic Shifts in Chick Myopia and Hyperopia Models.Life (Basel, Switzerland) · 2021Article
- SWATH Based Quantitative Proteomics Reveals Significant Lipid Metabolism in Early Myopic Guinea Pig Retina.International journal of molecular sciences · 2021Article
- Ocular growth and metabolomics are dependent upon the spectral content of ambient white light.Scientific reports · 2021Article
- Serum metabolic signatures of high myopia among older Chinese adults.Eye (London, England) · 2021Article
- Omics in Myopia.Journal of clinical medicine · 2020Review
- Morphologic and biochemical changes in the retina and sclera induced by form deprivation high myopia in guinea pigs.BMC ophthalmology · 2020Article
- A serum metabolomics study of patients with nAMD in response to anti-VEGF therapy.Scientific reports · 2020Article
- Metabolomics and biomarkers in ocular matrix: beyond ocular diseases.International journal of ophthalmology · 2020Review
- Article
- Short term optical defocus perturbs normal developmental shifts in retina/RPE protein abundance.BMC developmental biology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinal metabolic changes have been suggested to be associated with myopia development. However, little is known about either their identity or time dependent behavior during this sight compromising process. To address these questions, gas chromatography time-of-flight mass spectrometry (GC-TOF/MS) was applied to compare guinea pig retinal metabolite levels in form deprivation (FD) eyes at 3 days and 2 weeks post FD with normal control (NC) eyes. Orthogonal partial least squares (OPLS) models discriminated between time dependent retinal metabolic profiles in the presence and absence of FD. Myopia severity was associated with more metabolic pattern differences in the FD than in the NC eyes. After 3 days of FD, 11 metabolite levels changed and after 2 weeks the number of differences increased to 16. Five metabolites continuously decreased during two weeks of FD. Two-way ANOVA of the changes identified by OPLS indicates that 15 out of the 22 metabolites differences were significant. Taken together, these results suggest that myopia progression is associated with an inverse relationship between increases in glucose accumulation and lipid level decreases in form-deprived guinea pig eyes. Such changes indicate that metabolomic studies are an informative approach to identify time dependent retinal metabolic alterations associated with this disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.