SynthesisScientific reports2017
Correlations between diffusion tensor imaging and levels of consciousness in patients with traumatic brain injury: a systematic review and meta-analysis.
Synthesis in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- When Music Loses Its Pleasure: Hippocampal Cingulum White Matter as a Structural Mediator of Musical Reward Decline in Aging.bioRxiv : the preprint server for biology · 2026Article
- Prognostic factors in prolonged disorders of consciousness: a narrative review.Reviews in the neurosciences · 2026Review
- Automated MRI Segmentation of Brainstem Nuclei Critical to Consciousness.Human brain mapping · 2025Observational
- Significance of the corpus callosum and inferior fronto-occipital fasciculus in recovery after traumatic brain injury.Neuroradiology · 2025Article
- Explaining recovery from coma with multimodal neuroimaging.Journal of neurology · 2024Observational
- Association Between Anatomic and Clinical Indicators of Injury Severity After Moderate-Severe Traumatic Brain Injury: A Pilot Study Using Multiparametric Magnetic Resonance Imaging.Neurotrauma reports · 2024Article
- Clinical Decision on Disorders of Consciousness After Acquired Brain Injury: Stepping Forward.Neuroscience bulletin · 2023Review
- Refined Analysis of Chronic White Matter Changes after Traumatic Brain Injury and Repeated Sports-Related Concussions: Of Use in Targeted Rehabilitative Approaches?Journal of clinical medicine · 2022Article
- Investigating the contribution of cytoarchitecture to diffusion MRI measures in gray matter using histology.Frontiers in neuroimaging · 2022Article
- Structural and functional connectivity of the ascending arousal network for prediction of outcome in patients with acute disorders of consciousness.Scientific reports · 2021Article
- A population-based study of head injury, cognitive function and pathological markers.Annals of clinical and translational neurology · 2021Article
- Characteristics of Brain White Matter Microstructure in HIV Male Patients With Primary Syphilis Co-Infection.Frontiers in neurology · 2021Article
- The splenium of the corpus callosum: embryology, anatomy, function and imaging with pathophysiological hypothesis.Neuroradiology · 2020Review
- Article
- Immune Tolerance Therapy: A New Method for Treatment of Traumatic Brain Injury.Chinese medical journal · 2018Review
- Brain Network Studies in Chronic Disorders of Consciousness: Advances and Perspectives.Neuroscience bulletin · 2018Review
- The polytrauma clinical triad in patients with chronic pain after motor vehicle collision.Journal of pain research · 2018Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traumatic brain injury (TBI) often leads to impaired consciousness. Recent diffusion tensor imaging studies associated consciousness with imaging metrics including fractional anisotropy (FA) and apparent diffusion coefficient (ADC). We evaluated their correlations and determined the best index in candidate regions. Six databases were searched, including PubMed and Embase, and 16 studies with 701 participants were included. Data from region-of-interest and whole-brain analysis methods were meta-analysed separately. The FA-consciousness correlation was marginal in the whole-brain white matter (r = 0.63, 95% CI [0.47, 0.79], p = 0.000) and the corpus callosum (CC) (r = 0.60, 95% CI [0.48, 0.71], p = 0.000), and moderate in the internal capsule (r = 0.48, 95% CI [0.24, 0.72], p = 0.000). Correlations with ADC trended negative and lacked significance. Further subgroup analysis revealed that consciousness levels correlated strongly with FA in the CC body (r = 0.66, 95% CI [0.43, 0.89]), moderately in the splenium (r = 0.58, 95% CI [0.38, 0.78]), but insignificantly in the genu. In conclusion, FA correlates better with consciousness levels than ADC in TBI. The degree of correlation varies among brain regions. The CC (especially its splenium and body) is a reliable candidate region to quantitatively reflect consciousness levels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.