ArticleScientific reports2017
Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Prevalence and risk factors of sheep and goats fasciolosis in Ethiopia: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2025Pooled it
- Prevalence and associated factors of schistosomiasis among domestic ruminants in Ethiopia: a systematic review and meta-analysis.Veterinary and animal science · 2025Review
- Appraisal of the Use of Proteomics Methodological Approaches and Technologies on Sheep and Goat Research and Clinical Work.Animals : an open access journal from MDPI · 2025Article
- Article
- Article
- An Update on the Pathogenesis of Fascioliasis: What Do We Know?Research and reports in tropical medicine · 2024Review
- Fasciolosis: pathogenesis, host-parasite interactions, and implication in vaccine development.Frontiers in veterinary science · 2023Review
- Two Distinct Superoxidase Dismutases (SOD) Secreted by the Helminth ParasiteAntioxidants (Basel, Switzerland) · 2022Article
- Exploring the role of macrophages in determining the pathogenesis of liver fluke infection.Parasitology · 2022Review
- Fasciolosis-An Increasing Challenge in the Sheep Industry.Animals : an open access journal from MDPI · 2022Review
- The Host Peritoneal Cavity Harbors Prominent Memory Th2 and Early Recall Responses to an Intestinal Nematode.Frontiers in immunology · 2022Article
- Pathogenicity and virulence of the liver flukesVirulence · 2021Article
- Immunodiagnosis of cattle fascioliasis using a 27 kDaVeterinary world · 2021Article
- Fasciola hepatica hijacks host macrophage miRNA machinery to modulate early innate immune responses.Scientific reports · 2021Article
- Timing of Transcriptomic Peripheral Blood Mononuclear Cell Responses of Sheep toFrontiers in immunology · 2021Article
- Autonomous Non Antioxidant Roles forFrontiers in cellular and infection microbiology · 2021Review
- Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed 'clamp-like' mechanism of binding and inhibition.BMC molecular and cell biology · 2020Article
- Fasciola hepatica serine protease inhibitor family (serpins): Purposely crafted for regulating host proteases.PLoS neglected tropical diseases · 2020Article
- The application of proteomics in the diagnosis and treatment of bronchial asthma.Annals of translational medicine · 2020Review
- An Evaluation of theFrontiers in immunology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune signatures of sheep acutely-infected with Fasciola hepatica, an important pathogen of livestock and humans were analysed within the peritoneal compartment to investigate early infection. Within the peritoneum, F. hepatica antibodies coincided with an intense innate and adaptive cellular immune response, with infiltrating leukocytes and a marked eosinophilia (49%). However, while cytokine qPCR analysis revealed IL-10, IL-12, IL-13, IL-23 and TGFβ were elevated, these were not statistically different at 18 days post-infection compared to uninfected animals indicating that the immune response is muted and not yet skewed to a Th2 type response that is associated with chronic disease. Proteomic analysis of the peritoneal fluid identified infection-related proteins, including several structural proteins derived from the liver extracellular matrix, connective tissue and epithelium, and proteins related to the immune system. Periostin and vascular cell adhesion protein 1 (VCAM-1), molecules that mediate leukocyte infiltration and are associated with inflammatory disorders involving marked eosinophilia (e.g. asthma), were particularly elevated in the peritoneum. Immuno-histochemical studies indicated that the source of periostin and VCAM-1 was the inflamed sheep liver tissue. This study has revealed previously unknown aspects of the immunology and pathogenesis associated with acute fascioliasis in the peritoneum and liver.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.