ArticleChinese medical journal2017
Ovarian Damages Produced by Aerosolized Fine Particulate Matter (PM
Article in Chinese medical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Association between ambient air pollution exposure and pregnancy outcomes in women treated with assisted reproductive technology: an updated systematic review and meta-analysis.BMC public health · 2025Pooled it
- Assessment of ovarian dysfunction induced by environmental toxins: a systematic review.Frontiers in public health · 2025Pooled it
- Air pollutants and ovarian reserve: a systematic review of the evidence.Frontiers in public health · 2024Pooled it
- Exploring the nexus between particulate matter and infertility: Multiple mechanistic insights and potential control strategies.iScience · 2026Review
- Women's health and female fertility: current evidence and knowledge gaps in the Asia-Pacific region.The Lancet regional health. Western Pacific · 2025Review
- Association of Deficiency in Vitamin D, Vitamin E, and Selenium Levels With Premature Ovarian Insufficiency: A Systematic Review.Health science reports · 2025Review
- Effects of atmospherically relevant PMFrontiers in public health · 2025Review
- Very Early Pregnancy Loss: The Role of PMEnvironment & health (Washington, D.C.) · 2024Article
- Observed Effects on Very Early Pregnancy Linked to Ambient PMEnvironment & health (Washington, D.C.) · 2024Article
- Timing determines programming of energy homeostasis by maternal PMEnvironmental pollution (Barking, Essex : 1987) · 2024Article
- Review
- Air pollution exposure in vitrified oocyte donors and male recipient partners in relation to fertilization and embryo quality.Environment international · 2024Article
- The effects of inhaled pollutants on reproduction in marginalized communities: a contemporary review.Inhalation toxicology · 2024Review
- Associations between exposure to air pollution and sex hormones during the menopausal transition.The Science of the total environment · 2024Article
- Exposure to air pollution and ovarian reserve parameters.Scientific reports · 2024Article
- Circulating Interleukin-6 Mediates PMResearch (Washington, D.C.) · 2024Article
- Ambient traffic related air pollution in relation to ovarian reserve and oocyte quality in young, healthy oocyte donors.Environment international · 2024Article
- A comprehensive review on endocrine toxicity of gaseous components and particulate matter in smog.Frontiers in endocrinology · 2024Review
- Impact of NAD+ metabolism on ovarian aging.Immunity & ageing : I & A · 2023Review
- Air pollution and fecundability in a North American preconception cohort study.Environment international · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmbient aerosol fine particulate matter (PM2.5) is associated with male reproductive toxicity in experiments and may have adverse effects in the female. However, studies evaluating the protective effects and precise mechanisms of aspirin, Vitamin C, Vitamin E, or ozone against toxic effects of PM2.5are sparse. This study was conducted to investigate the possible protective effects and mechanisms of aspirin, Vitamin C, Vitamin E, or ozone on fertility in female mice treated with PM2.5.
methodsEighty-four ICR mice were divided into six groups: control group, PM2.5group, PM2.5 + aspirin group, PM2.5 + Vitamin C group, PM2.5 + Vitamin E group, and PM2.5 + ozone group. PM2.5was given by intratracheal instillation every 2 days for 3 weeks. Aspirin, Vitamin C, and Vitamin E were given once a day by oral gavage for 3 weeks, and ozone was administered by intraperitoneal injection once a day for 3 weeks. The levels of anti-Müllerian hormone (AMH), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured using enzyme-linked immunosorbent assay. Western blotting analysis was used to analyze the expressions of Bcl-2, Bax, and caspase-3 in ovaries. Changes in histological structure were examined by light microscope and electron microscopy was used to detect ultramicrostructure.
resultsThe results demonstrated that PM2.5 decreased AMH levels (P < 0.001); however, aspirin (P < 0.001), Vitamin C (P < 0.001), Vitamin E (P = 0.001), and ozone (P = 0.002) alleviated the decrease. Changes of IL-6, TNF-α, 8-OHdG, Bax/Bcl-2, and caspase-3 in PM2.5group were increased compared to control group (P < 0.001), while in PM2.5 + aspirin, PM2.5 + Vitamin C, PM2.5 + Vitamin E, and PM2.5 + ozone groups, they were statistically decreased compared to PM2.5group (P < 0.001 or P< 0.05).
conclusionsPM2.5cause the damage of ovaries, and aspirin, Vitamin C, Vitamin E, and ozone antagonizes the damage. The protective mechanism is probably due to its ability to blunt the inflammatory and oxidative stress caused by PM2.5, which subsequently suppressing the expression of apoptotic regulatory protein and reducing the incidence of ovary apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.