Evidence map›Paper›PMID 28584151›Full record

ArticleAntimicrobial agents and chemotherapy2017

Discovery and Characterization of a Novel CD4-Binding Adnectin with Potent Anti-HIV Activity.

David Wensel, Yongnian Sun, Zhufang Li, Sharon Zhang, Caryn Picarillo, Thomas McDonagh, David Fabrizio, Mark Cockett, Mark Krystal, Jonathan Davis

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Miniproteins as a Powerful Modality in Drug Development.Trends in biochemical sciences · 2020
    Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

David WenselDepartment of Molecular Discovery Technologies, Bristol-Myers Squibb, Waltham, Massachusetts, USA david.l.wensel@viivhealthcare.com.
Yongnian SunDepartment of Virology, Bristol-Myers Squibb, Wallingford, Connecticut, USA.
Zhufang LiDepartment of Virology, Bristol-Myers Squibb, Wallingford, Connecticut, USA.
Sharon ZhangDepartment of Virology, Bristol-Myers Squibb, Wallingford, Connecticut, USA.
Caryn PicarilloDepartment of Molecular Discovery Technologies, Bristol-Myers Squibb, Waltham, Massachusetts, USA.
Thomas McDonaghDepartment of Molecular Discovery Technologies, Bristol-Myers Squibb, Waltham, Massachusetts, USA.
David FabrizioDepartment of Virology, Bristol-Myers Squibb, Wallingford, Connecticut, USA.
Mark CockettDepartment of Virology, Bristol-Myers Squibb, Wallingford, Connecticut, USA.
Mark KrystalDepartment of Virology, Bristol-Myers Squibb, Wallingford, Connecticut, USA.
Jonathan DavisDepartment of Molecular Discovery Technologies, Bristol-Myers Squibb, Waltham, Massachusetts, USA.
Bristol-Myers Squibb (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel fibronectin-based protein (Adnectin) HIV-1 inhibitor was generated using

Indexed as

Anti-HIV AgentsCD4 AntigensCell LineCell Surface Display TechniquesEpitopesFibronectinsGlycosylationHEK293 CellsHIV-1HIV Envelope Protein gp120HIV Envelope Protein gp160HumansProtein BindingAnti-HIV AgentsCD4 AntigensEpitopesFibronectinsgp160 protein, Human immunodeficiency virus 1HIV Envelope Protein gp120HIV Envelope Protein gp160AdnectinCD4gp41HIV inhibitorhuman immunodeficiency virusN17

Identifiers

PMID28584151
PMCPMC5527662
OpenAlexW2624498887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.