Evidence map›Paper›PMID 28584117›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Histamine modulation of the basal ganglia circuitry in the development of pathological grooming.

Maximiliano Rapanelli, Luciana Frick, Haruhiko Bito, Christopher Pittenger

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Sex Differences in Histamine Regulation of Striatal Dopamine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Neural substrates for regulating self-grooming behavior in rodents.Journal of Zhejiang University. Science. B · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. The Multi-Targeting Ligand ST-2223 with Histamine HInternational journal of molecular sciences · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Maximiliano RapanelliDepartment of Psychiatry, Yale University hool of Medicine, New Haven, CT 06510.
Luciana FrickDepartment of Psychiatry, Yale University hool of Medicine, New Haven, CT 06510.
Haruhiko BitoDepartment of Neurochemistry, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.ORCID 0000-0001-6315-9594
Christopher PittengerDepartment of Psychiatry, Yale University hool of Medicine, New Haven, CT 06510; christopher.pittenger@yale.edu.ORCID 0000-0003-2117-9321
Yale University · USThe University of Tokyo · JP

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Histamine Regulation of the Basal Ganglia and the Pathophysiology of TicsR01NS101104 · NINDS · YALE UNIVERSITY · PI PITTENGER, CHRISTOPHER JOHN · 2017 to 2021
$2.3M
Pathophysiologically Realistic Mouse Models of Neuropsychiatric Disease: TouretteR01MH091861 · NIMH · YALE UNIVERSITY · PI PITTENGER, CHRISTOPHER JOHN · 2010 to 2014
$2.0M
NCATS NIH HHS UL1 TR001863NIMH NIH HHS R01 MH091861NINDS NIH HHS R01 NS101104
6 · The paper itself

Abstract

Aberrant histaminergic function has been proposed as a cause of tic disorders. A rare mutation in the enzyme that produces histamine (HA), histidine decarboxylase (HDC), has been identified in patients with Tourette syndrome (TS).

Indexed as

AnimalsBasal GangliaCorpus StriatumGroomingHistamineHistidine DecarboxylaseMiceMice, KnockoutNeuronsPrefrontal CortexSpinal Cord Dorsal HornTourette SyndromeHistamineHistidine Decarboxylasebasal gangliagroominghistaminestriatumTourette syndrome

Identifiers

PMID28584117
PMCPMC5488951
OpenAlexW2622099971

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.