ArticleProceedings of the National Academy of Sciences of the United States of America2017
Phosphorylation and negative regulation of CONSTITUTIVELY PHOTOMORPHOGENIC 1 by PINOID
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- BR-ENHANCED EXPRESSION 1/2/3 fine-tune plant photomorphogenesis by regulating the phyA/B-SPA1 cascade.The Plant cell · 2026Article
- Sucrose-activated TOR and phyA signaling alleviates shade-mediated inhibition of leaf development in Arabidopsis.Nature communications · 2026Article
- Inactivation of GH3.5 by COP1-mediated K63-linked ubiquitination promotes seedling hypocotyl elongation.Nature communications · 2025Article
- Shade-induced ROS/NO reinforce COP1-mediated diffuse cell growth.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Light regulates nuclear detainment of intron-retained transcripts through COP1-spliceosome to modulate photomorphogenesis.Nature communications · 2024Article
- PINOID-centered genetic interactions mediate auxin action in cotyledon formation.Plant direct · 2024Review
- Green means go: Green light promotes hypocotyl elongation via brassinosteroid signaling.The Plant cell · 2023Article
- Regulation of Plant Photoresponses by Protein Kinase Activity of Phytochrome A.International journal of molecular sciences · 2023Review
- The apple BTB protein MdBT2 positively regulates MdCOP1 abundance to repress anthocyanin biosynthesis.Plant physiology · 2022Article
- Physiological and transcriptome analysis of Magnolia denudata leaf buds during long-term cold acclimation.BMC plant biology · 2021Article
- Illuminating the COP1/SPA Ubiquitin Ligase: Fresh Insights Into Its Structure and Functions During Plant Photomorphogenesis.Frontiers in plant science · 2021Review
- PINOID regulates floral organ development by modulating auxin transport and interacts with MADS16 in rice.Plant biotechnology journal · 2020Article
- SlREM1 Triggers Cell Death by Activating an Oxidative Burst and Other Regulators.Plant physiology · 2020Article
- The Photomorphogenic Central Repressor COP1: Conservation and Functional Diversification during Evolution.Plant communications · 2020Review
- Article
- Plant Phytochromes and their Phosphorylation.International journal of molecular sciences · 2019Review
- Reply to Jin and Zhu: PINOID-mediated COP1 phosphorylation matters in photomorphogenesis inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Role of PINOID-mediated COP1 phosphorylation inProceedings of the National Academy of Sciences of the United States of America · 2017Article
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7 authors at 4 institutions in 2 countries.
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Abstract
CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) plays crucial roles in various cellular processes via its E3 ubiquitin ligase activity in organisms, ranging from fungi to humans. As a key component in regulating various biological events, COP1 itself is precisely controlled at multiple layers. Here, we report a negative regulator of COP1, PINOID (PID), which positively mediates photomorphogenic development. Specifically, PID genetically and physically interacts with COP1 and directly phosphorylates COP1 at Ser20. As a result, this posttranslational modification serves to repress COP1 activity and promote photomorphogenesis. Our findings signify a key regulatory mechanism for precisely maintaining COP1 activity, thereby ensuring appropriate development in plants.
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