ArticleProceedings of the National Academy of Sciences of the United States of America2017
Paleogenomics of echinoids reveals an ancient origin for the double-negative specification of micromeres in sea urchins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- But the Clock, Tick-Tock: An Empirical Case Study Highlights the Preeminence of Relaxed Clock Models in Total-Evidence Dating.Systematic biology · 2026Article
- Prickly Defenders: A Review of Venomous Sea Urchins (Echinoidea).Marine drugs · 2025Review
- Phylogenomic analyses of echinoid diversification prompt a re-evaluation of their fossil record.eLife · 2022Article
- Developmental atlas of the indirect-developing sea urchinFrontiers in cell and developmental biology · 2022Article
- Article
- The first complete mitochondrial genome of the sand dollar Sinaechinocyamus mai (Echinoidea: Clypeasteroida).Genomics · 2020Article
- Article
- Cell type phylogenetics informs the evolutionary origin of echinoderm larval skeletogenic cell identity.Communications biology · 2019Article
- A phylogenomic resolution of the sea urchin tree of life.BMC evolutionary biology · 2018Article
- From genome to anatomy: The architecture and evolution of the skeletogenic gene regulatory network of sea urchins and other echinoderms.Genesis (New York, N.Y. : 2000) · 2018Review
- Towards a Dynamic Interaction Network of Life to unify and expand the evolutionary theory.BMC biology · 2018Review
- Notch-mediated lateral inhibition is an evolutionarily conserved mechanism patterning the ectoderm in echinoids.Development genes and evolution · 2018Article
- Gene regulatory networks and network models in development and evolution.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Establishing a timeline for the evolution of novelties is a common, unifying goal at the intersection of evolutionary and developmental biology. Analyses of gene regulatory networks (GRNs) provide the ability to understand the underlying genetic and developmental mechanisms responsible for the origin of morphological structures both in the development of an individual and across entire evolutionary lineages. Accurately dating GRN novelties, thereby establishing a timeline for GRN evolution, is necessary to answer questions about the rate at which GRNs and their subcircuits evolve, and to tie their evolution to paleoenvironmental and paleoecological changes. Paleogenomics unites the fossil record and all aspects of deep time, with modern genomics and developmental biology to understand the evolution of genomes in evolutionary time. Recent work on the regulatory genomic basis of development in cidaroid echinoids, sand dollars, heart urchins, and other nonmodel echinoderms provides an ideal dataset with which to explore GRN evolution in a comparative framework. Using divergence time estimation and ancestral state reconstructions, we have determined the age of the double-negative gate (DNG), the subcircuit which specifies micromeres and skeletogenic cells in
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