Evidence map›Paper›PMID 28584076›Full record

ArticleJournal of leukocyte biology2017

Frontline Science: Aspirin-triggered resolvin D1 controls herpes simplex virus-induced corneal immunopathology.

Naveen K Rajasagi, Siddheshvar Bhela, Siva Karthik Varanasi, Barry T Rouse

Open access · bronzeAbstract read
In one paragraph

Article in Journal of leukocyte biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 54 citations in OpenAlex.

  1. Review
  2. Article
  3. Regulatory role of microRNAs in virus-mediated inflammation.Journal of inflammation (London, England) · 2024
    Review
  4. Neutrophils in Ocular Diseases.International journal of molecular sciences · 2024
    Review
  5. Article
  6. Review
  7. Targeting Angiogenesis via Resolution of Inflammation.Cold Spring Harbor perspectives in medicine · 2023
    Review
  8. Review
  9. Review
  10. Clinical Management of Herpes Simplex Virus Keratitis.Diagnostics (Basel, Switzerland) · 2022
    Review
  11. Loss of 15-lipoxygenase disrupts TCell death and differentiation · 2021
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Naveen K RajasagiBiomedical and Diagnostic Sciences, College of Veterinary Medicine, The University of Tennessee, Knoxville, Tennessee, USA; and nrajasag@utk.edu.
Siddheshvar BhelaBiomedical and Diagnostic Sciences, College of Veterinary Medicine, The University of Tennessee, Knoxville, Tennessee, USA; and.
Siva Karthik VaranasiDepartment of Genome Science and Technology, The University of Tennessee, Knoxville, Tennessee, USA.
Barry T RouseBiomedical and Diagnostic Sciences, College of Veterinary Medicine, The University of Tennessee, Knoxville, Tennessee, USA; and btr@utk.edu.
University of Tennessee at Knoxville · US

Funding

Mechanisms of Herpetic KeratitisR01EY005093 · NEI · UNIVERSITY OF TENNESSEE KNOXVILLE · PI ROUSE, BARRY T. · 1985 to 2020
$7.8M
Controlling Ocular Inflammation With Lipid Mediators Derived From Omega-3 Fatty AR21EY023027 · NEI · UNIVERSITY OF TENNESSEE KNOXVILLE · PI RAJASAGI, NAVEEN KUMAR · 2014 to 2015
$398k
NEI NIH HHS R01 EY005093NEI NIH HHS R21 EY023027
6 · The paper itself

Abstract

Stromal keratitis (SK) is a chronic immunopathological lesion of the eye, caused by HSV-1 infection, and a common cause of vision impairment in humans. The inflammatory lesions in the cornea are primarily caused by neutrophils with the active participation of CD4

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalAntiviral AgentsAspirinChemokine CCL2Chemokine CXCL2Corneal NeovascularizationCorneal StromaDocosahexaenoic AcidsFemaleGene Expression RegulationHerpes SimplexHerpesvirus 1, HumanHumansInterleukinsKeratitis, HerpeticAnti-Inflammatory Agents, Non-SteroidalAntiviral AgentsAspirinCcl2 protein, mouseChemokine CCL2Chemokine CXCL2Cxcl2 protein, mouseDocosahexaenoic AcidsInterleukinsMatrix Metalloproteinase 9MicroRNAsMmp9 protein, mouseresolvin D1Vascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseinflammationresolvinsstromal keratitis

Identifiers

PMID28584076
PMCPMC5636045
OpenAlexW2622415849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.