Evidence map›Paper›PMID 28584074›Full record

Observational studyJournal of the American Heart Association2017

Gut-Derived Serum Lipopolysaccharide is Associated With Enhanced Risk of Major Adverse Cardiovascular Events in Atrial Fibrillation: Effect of Adherence to Mediterranean Diet.

Daniele Pastori, Roberto Carnevale, Cristina Nocella, Marta Novo, Maria Santulli, Vittoria Cammisotto, Danilo Menichelli, Pasquale Pignatelli, Francesco Violi

Registry-linked trialOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01882114 (Study of Atherosclerotic Risk Factors and Oxidative Stress in Atrial Fibrillation. Relation to Cardiovascular Events), which is not on this map. Cited by 103 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 3 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01882114 unknown statusnot on this map

Study of Atherosclerotic Risk Factors and Oxidative Stress in Atrial Fibrillation. Relation to Cardiovascular Events

TypeobservationalSponsorUniversity of Roma La SapienzaRan2007 to 2020Enrolled3,000ConditionsAtrial Fibrillation, Metabolic Syndrome, Oxidative Stress, Atherosclerosis
3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 3 syntheses or guidelines pooled it, 170 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Dietary interventions in the management of atrial fibrillation.Frontiers in cardiovascular medicine · 2024
    Pooled it
  4. Review
  5. The gut-heart axis in cardio-oncology.Cardiovascular research · 2026
    Review
  6. Review
  7. mBio · 2026
    Article
  8. The AntioxidantAntioxidants (Basel, Switzerland) · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Daniele PastoriI Clinica Medica, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Italy.
Roberto CarnevaleI Clinica Medica, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Italy.
Cristina NocellaI Clinica Medica, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Italy.
Marta NovoI Clinica Medica, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Italy.
Maria SantulliI Clinica Medica, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Italy.
Vittoria CammisottoI Clinica Medica, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Italy.
Danilo MenichelliI Clinica Medica, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Italy.
Pasquale PignatelliI Clinica Medica, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Italy.
Francesco VioliI Clinica Medica, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Italy francesco.violi@uniroma1.it.
Sapienza University of Rome · ITPoliclinico Umberto I · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGut microbiota is emerging as a novel risk factor for atherothrombosis, but the predictive role of gut-derived lipopolysaccharide (LPS) is unknown. We analyzed (1) the association between LPS and major adverse cardiovascular events (MACE) in atrial fibrillation (AF) and (2) its relationship with adherence to a Mediterranean diet (Med-diet). METHODS AND

resultsThis was a prospective single-center study including 912 AF patients treated with vitamin K antagonists (3716 patient-years). The primary end point was a composite of MACE. Baseline serum LPS, adherence to Med-diet (n=704), and urinary excretion of 11-dehydro-thromboxane B

conclusionsIn this cohort of AF patients, LPS levels were predictive of MACE and negatively affected by high adherence to Med-diet. LPS may contribute to MACE incidence in AF by increasing platelet activation.

Indexed as

Diet, MediterraneanGastrointestinal MicrobiomePatient ComplianceAgedAged, 80 and overAnticoagulantsAtrial FibrillationBacteriaBiomarkersCerebrovascular DisordersFemaleHumansIntestinesKaplan-Meier EstimateLipopolysaccharidesMaleAnticoagulantsBiomarkersLipopolysaccharidesVitamin Katrial fibrillationcardiovascular eventslipopolysaccharideMediterranean dietthromboxane

Identifiers

PMID28584074
PMCPMC5669181
OpenAlexW2623414143

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.