Evidence map›Paper›PMID 28584069›Full record

ArticleArchives of disease in childhood2017

Developing guidelines in low-income and middle-income countries: lessons from Kenya.

Mike English, Grace Irimu, Rachel Nyamai, Fred Were, Paul Garner, Newton Opiyo

Abstract read
In one paragraph

Article in Archives of disease in childhood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The Dilemmas and Opportunities of Co-Creating Health Interventions to Fit Local Contexts: An Ethnographic Study on the Adaptation of Clinical Guidelines in Tanzania.Health expectations : an international journal of public participation in health care and health policy · 2024
    Trial
  3. National guideline development and adaptation, Egypt.Bulletin of the World Health Organization · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. From guideline to bedside, improving evidenced-base care.Trauma surgery & acute care open · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Antibiotic use in Kenyan public hospitals: Prevalence, appropriateness and link to guideline availability.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
    Article
  16. Observational
  17. Observational
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mike EnglishHealth Serviecs Unit, KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya.
Grace IrimuDepartment of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Rachel NyamaiMaternal, Newborn, Adolescent and Child Health Unit, Ministry of Health, Nairobi, Kenya.
Fred WereKenya Paediatric Association, Nairobi, Kenya.
Paul GarnerCentre for Evidence Synthesis for Global Health, Liverpool School of Tropical Medicine, Liverpool, UK.
Newton OpiyoHealth Services Unit, KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya.

Funding

Wellcome TrustWellcome Trust 076827Wellcome Trust 092654Wellcome Trust 097170
6 · The paper itself

Abstract

There are few examples of sustained nationally organised, evidence-informed clinical guidelines development processes in Sub-Saharan Africa. We describe the evolution of efforts from 2005 to 2015 to support evidence-informed decision making to guide admission hospital care practices in Kenya. The approach to conduct reviews, present evidence, and structure and promote transparency of consensus-based procedures for making recommendations improved over four distinct rounds of policy making. Efforts to engage important voices extended from government and academia initially to include multiple professional associations, regulators and practitioners. More than 100 people have been engaged in the decision-making process; an increasing number outside the research team has contributed to the conduct of systematic reviews, and 31 clinical policy recommendations has been developed. Recommendations were incorporated into clinical guideline booklets that have been widely disseminated with a popular knowledge and skills training course. Both helped translate evidence into practice. We contend that these efforts have helped improve the use of evidence to inform policy. The systematic reviews, Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approaches and evidence to decision-making process are well understood by clinicians, and the process has helped create a broad community engaged in evidence translation together with a social or professional norm to use evidence in paediatric care in Kenya. Specific sustained efforts should be made to support capacity and evidence-based decision making in other African settings and clinical disciplines.

Indexed as

Practice Guidelines as TopicChildChild Health ServicesDecision MakingDiffusion of InnovationEvidence-Based MedicineGuideline AdherenceHospitalizationHumansKenyaPatient AdmissionPolicy MakingPovertyEvidence Based MedicineGuidelinesPaediatric PracticeTropical Paediatrics

Identifiers

PMID28584069
PMCPMC5564491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.