Evidence map›Paper›PMID 28583773›Full record

ArticleVeterinary anaesthesia and analgesia2017

Anesthetic synergy between two n-alkanes.

Robert J Brosnan, Fabíola B Fukushima, Trung L Pham

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary anaesthesia and analgesia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Robert J BrosnanDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA. Electronic address: rjbrosnan@ucdavis.edu.
Fabíola B FukushimaDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
Trung L PhamDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
University of California, Davis · US

Funding

Does Anesthetic Solubility Determine Receptor Specificity?R01GM092821 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BROSNAN, ROBERT JOSEPH · 2010 to 2013
$1.1M
NIGMS NIH HHS R01 GM092821
6 · The paper itself

Abstract

objectiveN-butane and n-pentane can both produce general anesthesia. Both compounds potentiate γ-aminobutyric acid type A (GABA STUDY

designProspective experimental study. ANIMALS: A total of four Xenopus laevis frogs and 43 Sprague-Dawley rats.

methodsAlkane concentrations for all studies were determined via gas chromatography. Using a Xenopus oocyte expression model, standard two-electrode voltage clamp techniques were used to measure NMDA and GABA

resultsBoth butane and pentane dose-dependently potentiated GABA

conclusionsButane and pentane show synergistic anesthetic effects in vivo consistent with their different in vitro receptor effects. CLINICAL RELEVANCE: Findings support the relevance of NMDA receptors in mediating anesthetic actions for some, but not all, inhaled agents.

Indexed as

AnestheticsAnesthetics, InhalationAnimalsButanesChromatography, GasDrug SynergismN-MethylaspartatePatch-Clamp TechniquesPentanesProspective StudiesRatsRats, Sprague-DawleyReceptors, GABA-AReceptors, N-Methyl-D-AspartateXenopus laevisAnestheticsAnesthetics, InhalationbutaneButanesN-MethylaspartatepentanePentanesReceptors, GABA-AReceptors, N-Methyl-D-Aspartateinhaled anestheticsisobologrammechanism of actionminimum alveolar concentrationN-methyl-d-aspartate receptorγ-aminobutyric acid type A receptor

Identifiers

PMID28583773
PMCPMC5505817
OpenAlexW2573896381

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.