ArticleEBioMedicine2017
Visual and Motor Deficits in Grown-up Mice with Congenital Zika Virus Infection.
Article in EBioMedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 62 citations in OpenAlex.
- Alterations in the Components of the GABA-Glutamate System During ZIKV Infection: A Neuroscience Approach.International journal of molecular sciences · 2026Article
- Flaviviruses-Induced Neurological Sequelae.Pathogens (Basel, Switzerland) · 2024Review
- Postnatal Zika virus infection leads to morphological and cellular alterations within the neurogenic niche.Disease models & mechanisms · 2024Article
- Laboratory Animal Models for Rift Valley Fever Virus Disease.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Brain methylome remodeling selectively regulates neuronal activity genes linking to emotional behaviors in mice exposed to maternal immune activation.Nature communications · 2023Article
- Morphological and Molecular Changes in the Cortex and Cerebellum of Immunocompetent Mice Infected with Zika Virus.Viruses · 2023Article
- Zika virus induced microcephaly and aberrant hematopoietic cell differentiation modeled in novel neonatal humanized mice.Frontiers in immunology · 2023Article
- Neurological consequences of neurovascular unit and brain vasculature damages: potential risks for pregnancy infections and COVID-19-babies.The FEBS journal · 2022Review
- sEVsMolecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- Article
- Embryonic Stage of Congenital Zika Virus Infection Determines Fetal and Postnatal Outcomes in Mice.Viruses · 2021Article
- Reversing neural circuit and behavior deficit in mice exposed to maternal inflammation by Zika virus.EMBO reports · 2021Article
- Zika virus induces neuronal and vascular degeneration in developing mouse retina.Acta neuropathologica communications · 2021Article
- Animal models of congenital zika syndrome provide mechanistic insight into viral pathogenesis during pregnancy.PLoS neglected tropical diseases · 2020Review
- A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy.PloS one · 2020Article
- Protein- and Peptide-Based Virus Inactivators: Inactivating Viruses Before Their Entry Into Cells.Frontiers in microbiology · 2020Review
- Protection of ZIKV infection-induced neuropathy by abrogation of acute antiviral response in human neural progenitors.Cell death and differentiation · 2019Article
- Erythromycin Estolate Inhibits Zika Virus Infection by Blocking Viral Entry as a Viral Inactivator.Viruses · 2019Article
- Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells.Nature communications · 2019Article
- Directional entry and release of Zika virus from polarized epithelial cells.Virology journal · 2019Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human infants with congenital Zika virus (ZIKV) infection exhibit a range of symptoms including microcephaly, intracranial calcifications, macular atrophy and arthrogryposis. More importantly, prognosis data have lagged far behind the recent outbreak of ZIKV in 2015. In this work, we allow congenitally ZIKV-infected mice to grow into puberty. These mice exhibited motor incoordination and visual dysfunctions, which can be accounted by anatomical defects in the retina and cerebellar cortex. In contrary, anxiety level of the ZIKV-infected mice is normal. The spectrum of anatomical and behavioral deficits is consistent across different mice. Our data provided evidence that may help predict the public health burden in terms of prognosis of ZIKV-related congenital brain malformations in an animal model. Our study provided behavioral evaluation for the prognosis of congenital ZIKV infection and provides a platform for screening and evaluation of drugs candidates and treatment aiming at improving regeneration of infected neurons to prevent sequelae caused by ZIKV infection of fetus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.