ArticleParasites & vectors2017
Molecular signatures of neutrophil extracellular traps in human visceral leishmaniasis.
Article in Parasites & vectors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Neutrophil extracellular traps formation driven by novel ELANE mutations in cyclic neutropenia patients.Genes and immunity · 2026Article
- Neutrophil-ACS infectious diseases · 2025Article
- Mechanisms regulating host cell death duringmBio · 2024Review
- Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via the regulating pentose phosphate pathway.Molecular medicine (Cambridge, Mass.) · 2023Article
- Balancing the functions of DNA extracellular traps in intracellular parasite infections: implications for host defense, disease pathology and therapy.Cell death & disease · 2023Review
- Article
- NETosis in Parasitic Infections: A Puzzle That Remains Unsolved.International journal of molecular sciences · 2023Review
- Gene Signatures of Symptomatic and Asymptomatic Clinical-Immunological Profiles of Human Infection byMicroorganisms · 2023Article
- Prediction of prognosis and immunotherapy response in breast cancer based on neutrophil extracellular traps-related classification.Frontiers in molecular biosciences · 2023Article
- Protective effect of methyl gallate on murine antigen-induced arthritis by inhibiting inflammatory process and bone erosion.Inflammopharmacology · 2022Article
- Pan-Cancer Analysis Reveals a Distinct Neutrophil Extracellular Trap-Associated Regulatory Pattern.Frontiers in immunology · 2022Article
- Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity.Nature communications · 2021Article
- Neutrophil extracellular traps from healthy donors and HIV-1-infected individuals restrict HIV-1 production in macrophages.Scientific reports · 2020Article
- Transcriptional and proteomic insights into the host response in fatal COVID-19 cases.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Role of the lipoxin A4 receptor in the development of neutrophil extracellular traps in Leishmania infantum infection.Parasites & vectors · 2019Article
- Glutamine Therapy Reduces Inflammation and Extracellular Trap Release in Experimental Acute Respiratory Distress Syndrome of Pulmonary Origin.Nutrients · 2019Article
- Heme Drives Oxidative Stress-Associated Cell Death in Human Neutrophils Infected withFrontiers in immunology · 2017Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfections with parasites of the Leishmania donovani complex result in clinical outcomes that range from asymptomatic infection to severe and fatal visceral leishmaniasis (VL). Neutrophils are major players of the immune response against Leishmania, but their contribution to distinct states of infection is unknown. Gene expression data suggest the activation of the NETosis pathway during human visceral leishmaniasis. Thus, we conducted an exploratory study to evaluate NET-related molecules in retrospective sera from VL patients, asymptomatic individuals and uninfected endemic controls.
resultsWe demonstrate that VL patients and asymptomatic individuals exhibit differential regulation of molecules associated with neutrophil extracellular traps (NET). These differences were observed at the transcriptional level of genes encoding NET-associated proteins; in quantifications of cell free DNA and metalloproteinase 9; and in enzymatic activity of DNAse and elastase. Moreover, multivariate analysis resulted in class-specific signatures, and ROC curves demonstrate the ability of these molecules in discriminating asymptomatic infection from uninfected controls.
conclusionMolecules that are associated with NETs are differentially regulated between distinct states of infection with L. infantum, suggesting that NETs might have distinct roles depending on the clinical status of infection. Although unlikely to be exclusive for VL, these signatures can be useful to better characterize asymptomatic infections in endemic regions of this disease.
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