Evidence map›Paper›PMID 28583178›Full record

ReviewStem cell research & therapy2017

Therapeutic angiogenesis of adipose-derived stem cells for ischemic diseases.

Lina Zhao, Takerra Johnson, Dong Liu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 187 citations in OpenAlex.

  1. Review
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  5. Efficacy of the combination of umbilical fat and venous blood on limb salvage.Frontiers in bioengineering and biotechnology · 2026
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lina ZhaoCardiovascular Research Institute, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310, USA.
Takerra JohnsonCardiovascular Research Institute, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310, USA.
Dong LiuCardiovascular Research Institute, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310, USA. dliu@msm.edu.ORCID 0000-0002-0270-7312
Morehouse School of Medicine · US

Funding

Microvesicles from Adipose-derived Stem Cells for Ischemic Heart RepairSC1HL134212 · NHLBI · MOREHOUSE SCHOOL OF MEDICINE · PI LIU, DONG · 2016 to 2019
$1.4M
Proangiogenic microRNA in Microvesicles Released from Adipose-derived Stem CellsSC2GM099629 · NIGMS · MOREHOUSE SCHOOL OF MEDICINE · PI LIU, DONG · 2012 to 2014
$420k
NHLBI NIH HHS SC1 HL134212NIGMS NIH HHS SC2 GM099629
6 · The paper itself

Abstract

Ischemic diseases, the leading cause of disability and death, are caused by the stenosis or obstruction of arterioles/capillaries that is not compensated for by vessel dilatation or collateral circulation. Angiogenesis is a complex process leading to new blood vessel formation and is triggered by ischemic conditions. Adequate angiogenesis, as a compensatory mechanism in response to ischemia, may increase oxygen and nutrient supplies to tissues and protect their function. Therapeutic angiogenesis has been the most promising therapy for treating ischemic diseases. In recent years, stem cell transplantation has been recognized as a new technique with therapeutic angiogenic effects on ischemic diseases. Adipose-derived stem cells, characterized by their ease of acquisition, high yields, proliferative growth, and low immunogenicity, are an ideal cell source. In this review, the characterization of adipose-derived stem cells and the role of angiogenesis in ischemic attack are summarized. The angiogenic effects of adipose-derived stem cells are discussed from the perspectives of in-vitro, in-vivo, and clinical trial studies for the treatment of ischemic diseases, including ischemic cardiac, cerebral, and peripheral vascular diseases and wound healing. The microvesicles/exosomes released from adipose-derived stem cells are also presented as a novel therapeutic prospect for treating ischemic diseases.

Indexed as

Neovascularization, PhysiologicWound HealingAdipose TissueAnimalsBrain IschemiaCell- and Tissue-Based TherapyClinical Trials as TopicHeartHumansMyocardial IschemiaPeripheral Arterial DiseaseRatsStem CellsStem Cell TransplantationAdipose-derived stem cellsAngiogenesisIschemic diseasesProangiogenic effect

Identifiers

PMID28583178
PMCPMC5460534
OpenAlexW2624243169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.