Evidence map›Paper›PMID 28583125›Full record

ArticleInternational journal for equity in health2017

Considerations and guidance in designing equity-relevant clinical trials.

Lawrence Mbuagbaw, Theresa Aves, Beverley Shea, Janet Jull, Vivian Welch, Monica Taljaard, Manosila Yoganathan, Regina Greer-Smith, George Wells, Peter Tugwell

Registry-linked trialAbstract read
In one paragraph

Article in International journal for equity in health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04090177 (Evaluation of a Peer-led eHealth Wheelchair Skills Training Program), which is not on this map. Cited by 32 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04090177 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Evaluation of a Peer-led eHealth Wheelchair Skills Training Program: Training to Enhance Adaptation and Management for Wheelchair Users

TypeinterventionalSponsorUniversity of ManitobaRan2021 to 2024Enrolled54ConditionsMobility LimitationArmsTEAM Wheels
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Social determinants of health in studies using PROMs to assess toxicities associated with immune checkpoint inhibitor treatment: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  6. Randomized Comparison of Online Motivational Themes in Clinical Trial Recruitment.Circulation. Cardiovascular quality and outcomes · 2025
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  16. Equity and capacity to benefit from early access to medicines schemes.International journal for equity in health · 2025
    Review
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lawrence MbuagbawDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. mbuagblc@mcmaster.ca.
Theresa AvesDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Beverley SheaOttawa Hospital Research Institute, Center for Practice Changing Research and School of Epidemiology, Public Health and Preventive Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
Janet JullUniversity of Ottawa and Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, K1H 8M2, Canada.
Vivian WelchBruyère Research Institute, Ottawa, Canada.
Monica TaljaardClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Manosila YoganathanBruyère Research Institute, Bruyère Continuing Care and University of Ottawa, 85 Primrose, Ottawa, ON, Canada.
Regina Greer-SmithHealthcare Research Associates, 2700 Concord Place, Hazel Crest, IL, USA.
George WellsSchool of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Canada.
Peter TugwellSchool of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Health research has documented disparities in health and health outcomes within and between populations. When these disparities are unfair and avoidable they may be referred to as health inequities. Few trials attend to factors related to health inequities, and there is limited understanding about how to build consideration of health inequities into trials. Due consideration of health inequities is important to inform the design, conduct and reporting of trials so that research can build evidence to more effectively address health inequities and importantly, ensure that inequities are not aggravated. In this paper, we discuss approaches to integrating health equity-considerations in randomized trials by using the PROGRESS Plus framework (Place of residence, Race/ethnicity/culture/language, Occupation, Gender, Religion, Education, Socio-economic status, Social capital and "Plus" that includes other context specific factors) and cover: (i) formulation of research questions, (ii) two specific scenarios relevant to trials about health equity and (iii) describe how the PROGRESS Plus characteristics may influence trial design, conduct and analyses. This guidance is intended to support trialists designing equity-relevant trials and lead to better design, conduct, analyses and reporting, by addressing two main issues: how to avoid aggravating inequity among research participants and how to produce information that is useful to decision-makers who are concerned with health inequities.

Indexed as

Health EquityResearch DesignHealth Status DisparitiesHumansRandomized Controlled Trials as TopicDesignEducationEthnicityGenderHealth equityPROGRESS plusRandomized trialReligionSocio-economic

Identifiers

PMID28583125
PMCPMC5460332

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.