ArticleEnvironmental health : a global access science source2017
Newborn sex-specific transcriptome signatures and gestational exposure to fine particles: findings from the ENVIRONAGE birth cohort.
Article in Environmental health : a global access science source, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Optimal Timing to Utilize Olfactory Stimulation with Maternal Breast Milk to Improve Oral Feeding Skills in the Premature Newborn.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2019Trial
- Air pollution and autism-like traits: Sensitive periods and joint effects of exposure to sources and constituents of fine particulate matter.Environmental research · 2026Article
- Integrating omics and artificial intelligence in pediatric environmental health: tools, challenges, and cohort-based insights.Pediatric research · 2026Review
- Review
- Transcriptomics insight into occupational exposure to engineered nanoparticles.Nanomedicine (London, England) · 2025Article
- Differential regulation of gene co-expression modules in muscles and liver of preterm newborns.Frontiers in cell and developmental biology · 2025Article
- Prenatal Exposure to Metabolism-Disrupting Chemicals, Cord Blood Transcriptome Perturbations, and Birth Weight in a Belgian Birth Cohort.International journal of molecular sciences · 2023Article
- Future Health Risk Assessment of Exposure to PMToxics · 2023Article
- Assessing the influence of distinct culture media on human pre-implantation development using single-embryo transcriptomics.Frontiers in cell and developmental biology · 2023Article
- Prenatal exposure to particulate matter and placental gene expression.Environment international · 2022Article
- Article
- DNA methylation of insulin-like growth factor 2 and H19 cluster in cord blood and prenatal air pollution exposure to fine particulate matter.Environmental health : a global access science source · 2020Article
- Hippocampal transcriptome analysis following maternal separation implicates altered RNA processing in a mouse model of fetal alcohol spectrum disorder.Journal of neurodevelopmental disorders · 2020Article
- Maternal exposure to ambient fine particulate matter and fetal growth in Shanghai, China.Environmental health : a global access science source · 2019Article
- Pre- and postnatal exposure of mice to concentrated urban PMEnvironmental pollution (Barking, Essex : 1987) · 2018Article
- Integrating -Omics Approaches into Human Population-Based Studies of Prenatal and Early-Life Exposures.Current environmental health reports · 2018Review
- Next-generation sequencing and prenatal 'omics: advanced diagnostics and new insights into human development.Genetics in medicine : official journal of the American College of Medical Genetics · 2018Review
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAir pollution exposure during pregnancy has been associated with adverse birth outcomes and health problems later in life. We investigated sex-specific transcriptomic responses to gestational long- and short-term exposure to particulate matter with a diameter < 2.5 μm (PM
methodsWhole genome gene expression was investigated in cord blood of 142 mother-newborn pairs that were enrolled in the ENVIRONAGE birth cohort. Daily PM
resultsSome processes were altered in both sexes for long- (e.g. DNA damage) or short-term exposure (e.g. olfactory signaling). For long-term exposure in boys neurodevelopment and RhoA pathways were modulated, while in girls defensin expression was down-regulated. For short-term exposure we identified pathways related to synaptic transmission and mitochondrial function (boys) and immune response (girls).
conclusionsThis is the first whole genome gene expression study in cord blood to identify sex-specific pathways altered by PM
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.